, Volume 76, Issue 1, pp 94–95 | Cite as

Amitriptyline and nortriptyline excretion in human breast milk

  • L. Brixen-Rasmussen
  • J. Halgrener
  • A. Jørgensen
Short Reports


Simultaneous blood and milk samples were obtained from a 30-year-old woman who was on sustained release amitriptyline, and the concentrations of amitriptyline and the active metabolite, nortriptyline, were estimated by GLC. Serum and milk concentrations were similar with a slight tendency for the amitriptyline concentrations to be higher in milk. Calculation of the transfer of drug from the mother to the baby showed that the baby received an amitriptyline dose which was about one hundredth the dose given to the mother. No active drug could be estimated in the baby's serum and the baby showed no clinical signs which could be drug related.

Key words

Lactation Serum and milk concentrations Amitriptyline Nortriptyline 


  1. Bader TF, Newman K (1980) Amitriptyline in human breast milk and the nursing infant's serum. Am J Psychiatry 137:117–120Google Scholar
  2. Jørgensen A (1975) A gas chromatographic method for the determination of amitriptyline and nortriptyline in human serum. Acta Pharmacol Toxicol 36:79–90Google Scholar
  3. Sovner R, Orsulak PJ (1979) Excretion of imipramine and desipramine in human breast milk. Am J Psychiatry 136:451–452Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • L. Brixen-Rasmussen
    • 1
  • J. Halgrener
    • 2
  • A. Jørgensen
    • 3
  1. 1.Jysk NervesanatoriumVejlefjordVejleDenmark
  2. 2.HedenstedDenmark
  3. 3.Biochemical DepartmentH. Lundbeck & CO. A/SValbyDenmark

Personalised recommendations