Psychopharmacology

, Volume 76, Issue 1, pp 40–43 | Cite as

Central administration of arginine vasotocin: Effects on exploratory behavior in the rat

  • M. G. King
  • L. Stinus
  • M. le Moal
  • M. Geffard
Original Investigations

Abstract

Synthetic arginine vasotocin (AVT) was infused into rat brains either by intraventricular administration or by local infusion on the pineal body. Subsequently, exploratory behavior was analyzed in a hole board. The behavioral effects induced by this peptide were dependent on the time of day, i. e. the light or the dark phase. High intraventricular doses (0.4 μg) administered during the light phase altered exploratory activity such that the number of hole visits was increased, while the duration of each visit was decreased; lower doses producted no effect. In contrast, during the dark phase, peripineal infusion of AVT (10-4 pg) attenuated the number of hole visits and increased the mean duration of the visits. The strongest effects were obtained with peripineal applications during the dark phase. This treatment also resulted in significantly lowered levels of pineal melatonin.

Key words

Arginine vasotocin Melatonin Exploration 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Berlyne DE (1960) Conflict, arousal and curiosity. McGraw Hill, New YorkGoogle Scholar
  2. Datta PC, King MG (1977) Effects of melanocyte-stimulating hormone (MSH) and melatonin on passive avoidance and on an emotional response. Pharmacol Biochem Behav 6:449–452Google Scholar
  3. Datta PC, King MG (1979) Effects of MIF-1 and melatonin on novelty induced defecation and associated plasma 11-OHCS and brain catecholamines. Pharmacol Biochem Behav 11:173–181Google Scholar
  4. Datta PC, King MG (1980) Melatonin: Effects on brain and behaviour. Neurosci Biobehav Rev 4(4):451–459Google Scholar
  5. Datta PC, King MG (1980) Effects of α-MSH and melatonin on passive avoidance and on PA-induced defecation and plasma 11-OHCS in hypophysectomized rats. Peptides 1:147–153Google Scholar
  6. Geffard M, Puizillout JJ, Delaage MA (1981) Radioimmunoassay system for serotonin, N-acetylserotonin and melatonin. Int J Neurochem (in submission)Google Scholar
  7. Golus P, King MG (1981a) Arginine vasotocin: Effects on brain 5-hydroxytryptamine, plasma 11-hydroxycorticosterone and openfield behavior. Peptides (in press)Google Scholar
  8. Golus P, King MG (1981b) Melatonin and open-field behavior. Pharmacol Biochem Behav (in press)Google Scholar
  9. Golus P, McGee R, Power P, Meyers W, Bevan P, King MG (1981) Arginine vasotocin modifies novelty-induced behavior (to be published)Google Scholar
  10. King MG, Golus P, Power P (1981) Opposite effects of arginine vasotocin and α-melanocyte stimulating hormone on brain 5-hydroxytryptamine and plasma 11-hydroxycorticosterone. In: Dhawan BN (ed) Current status of centrally acting peptides. Pergamon, Oxford (in press)Google Scholar
  11. Pavel S (1978) Arginine vasotocin as a pineal hormone. J Neural Transm 13:135–155Google Scholar
  12. Pavel S (1979) The mechanism of action of vasotocin in the mammalian brain. In: Ariens Kappers J, Pevet P (eds) The pineal gland of vertebrates including man. Prog in Brain Res. vol 52. Elsevier, AmsterdamGoogle Scholar
  13. Pavel S, Ghinea E, Goldstein R, Matulevicius V (1978) Vasotocin biosynthesis by cultured pineal gland from adult male rats. J Endocrinol 77:147–147Google Scholar
  14. Pavel S, Goldstein R (1979) Further evidence that melatonin represents the releasing hormone for pineal vasotocin. J Endocrinol 82:1–6Google Scholar
  15. Pevet P, Dogteromm J, Buijs RM, Swaab DF, Janssens PM (1978) The presence of neuropeptides in the mammalian pineal and subcommisural organ. Neurosci Lett Suppl. 1:225Google Scholar
  16. Rougon-Rapuzzi G, Millet YA, Delaage MA (1977) Preparation of antivasopressin antibodies using an IgA carrier. Application to radio-immunoassay. Biochemie 59:939–942Google Scholar
  17. Walter R, van Ree JM, de Wied D (1978) Modification of conditioned behavior of rats by neurohypophyseal hormones and analogues. Proc Natl Acad Sci USA 75:2493–2496Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • M. G. King
    • 1
  • L. Stinus
    • 2
  • M. le Moal
    • 2
  • M. Geffard
    • 3
  1. 1.Department of PsychologyThe University of NewcastleNewcastleAustralia
  2. 2.Laboratory of Behavioural NeurobiologyUniversity of Bordeaux IIBordeauxFrance
  3. 3.C.N.R.S. Institute of Cellular Biochemistry and NeurochemistryUniversity of Bordeaux IIBordeauxFrance

Personalised recommendations