Summary
Herpesvirus SA 8 infections are occurring naturally in African green monkeys and baboons. Neither the clinical nor the morphological sequelae of SA 8 infections in homologous or heterologous hosts are sufficiently known. Therefore, colony-born baboons of three age groups were inoculated intravenously or intratracheally, using a SA 8 strain (strain 0430) isolated from fatally infected newborn baboons. Of all experimental animals, 63% developed focal encephalitis, characterized predominantly by glial nodule formation and necrosis of nerve and glial cells. Early stages of the infection (2–5 days after infection) were accompanied by inclusion body formation or by eosinophilic nerve cell degeneration. The distribution of the CNS lesions depended largely on the inoculation route. In intravenously inoculated newborn baboons, the inflammatory foci were scattered throughout the entire brain and spinal cord, including the leptomeninges, whereas these lesions were focused on the vagal root areas within the medulla oblongata in the intratracheally inoculated animals of all age groups. In the intratracheally infected animals corresponding herpetic lesions were also commonly found in pulmonary ganglia or pulmonary vagal branches. The possible vagal ascendance of herpesvirus SA 8 from the primarily affected lung to the brain in intratracheally inoculated animals is discussed.
Zusammenfassung
Herpesvirus SA 8 verursacht natürliche Infektionen grüner Meerkatzen und Paviane, ohne daß bisher die klinischen oder morphologischen Erscheinungen solcher Infektionen in homologen oder heterologen Wirten ausreichend bekannt wären. Mit einem aus gestorbenen neugeborenen Pavianen isolierten Stamm (Stamm 0430) wurden deshalb experimentell koloniegeborene Paviane aus drei Altersgruppen intravenös, bzw. intratracheal infiziert. Über die dabei erzielten Veränderungen des ZNS wird hier berichtet. Bei 63% aller Versuchstiere wurden herdförmige Gliaknoten-Encephalitiden oder Einschlußkörper-Encephalitiden erzeugt. Intravenöse Infektionen führten zu regellosem Verteilungsmuster der Entzündungsherde, während nach intratrachealen Infektionen überwiegend das Einflußgebiet des Nervus vagus in der Medulla oblongata befallen war. Korrespondierende Herpesvirusläsionen wurden in Pulmonalganglien intratracheal infizierter Paviane beobachtet. Die vagale Aszendenz des Virus von der primär befallenen Lunge zum ZNS wird diskutiert.
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Mit dankenswerter Unterstützung durch die Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg — Br 414/1, 2
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Brack, M., Eichberg, J.W., Heberling, R.L. et al. Experimentelle Herpesvirus SA 8 — Encephalitis bei Kenia-Pavianen (Papio cynocephalus). Virchows Arch. A Path. Anat. and Histol. 388, 199–212 (1980). https://doi.org/10.1007/BF00430688
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DOI: https://doi.org/10.1007/BF00430688