Summary
Three cases of medullary carcinoma complying with strictly defined criteria have been examined by electron microscopy. These carcinomas are characterised by the presence of light and dark tumour cells which exhibit prominent organelles and well-developed Golgi complexes but lack secretory activity. The essential stromal cellular infiltrate of macrophages, lymphocytes and plasma cells contains macrophage-lymphocyte clusters suggesting the existence of an immune response. Also present in the stroma are blood vessels lined by high-endothelial cells of the type said to facilitate lymphocyte migration.
It is suggested that light and dark tumour cells with well-developed organelles but absent secretory activity, macrophage-lymphocyte clusters and stromal high-endothelial venules represent specific ultrastructure features of typical medullary carcinoma associated with good prognosis.
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References
Ahmed A (1974) Electron microscopic observations of scirrhous and mucin-producing carcinomas of the breast. J Pathol 112:177–181
Ahmed A (1975) Calcification in human breast carcinomas: ultrastructural observations. J Pathol 117:247–251
Ahmed A (1978) Atlas of the ultrastructure of human breast diseases. Churchill-Livingstone, Edinburgh, London and New York, p 92
Anderson ND, Anderson AO, Wyllie RG (1976) Specialized structure and metabolic activities of high endothelial venules in rat lymphatic tissue. Immunology 31:455–473
Azzopardi JG (1979) Problems in breast pathology. In: Major problems in pathology, vol 11. WB Saunders Company Ltd, London, Philadelphia, Toronto p 288
Farr AG, De Bruyn PPH (1975) Macrophage lymphocyte clusters in lymph nodes: A possible substrate for cellular interactions in the immune response. Am J Anat 144:209–232
Fisher ER (1976) Ultrastructure of human breast and its disorders. Am J Clin Pathol 66:291–375
Gould VE, Miller J, Jao W (1975) Ultrastructure of medullary, intraductal, tubular and adenoid cystic carcinomas — Comparative patterns of myoepithelial differentiation and basal lamina deposition. Am J Pathol 78:401–416
Holbrook KA, Perkins WV, Glick B (1977) Contact sites between lymphoid cells of the bursa of Fabricius in vivo and in vitro. Anat Rec 189:567–576
Klein-Szanto AJP, Topping DC, Heckman CA, Nettesheim P (1980) Ultrastructural characteristics of carcinogen-induced dysplastic changes in tracheal epithelium. Am J Pathol 98:83–100
Michaud J, Morin J (1971) Ultrastructure d'un epithelioma medullaire de la glande mammaire. Laval Medical 42:496–507
Moore OS Jr, Foote FW Jr (1949) The relatively favorable prognosis of medullary carcinoma of the breast. Cancer 2:635–642
Murad TM, Scarpelli DG (1967) The ultrastructure of medullary and scirrhous mammary duct carcinoma. Am J Pathol 50:335–360
Richardson WW (1956) Medullary carcinoma of the breast: a distinctive tumour type with a relatively good prognosis following radical mastectomy. Br J Cancer 10:415–423
Ridolfi RL, Rosen PP, Port A, Kinne D, Miko V (1977) Medullary carcinoma of the breast. A clinicopathologic study with 10 year follow-up. Cancer 40:1365–1385
Schoorl R, Brutel de la Riviere A, Von dem Borne AEGK, Feltkamp-Vroom TM (1976) Identification of T and B lymphocytes in human breast cancer with immunohistochemical techniques. Am J Pathol 84:529–544
Underwood JCE, Carr I (1972) The ultrastructure of the lymphoreticular cells in non-lymphoid human neoplasms. Virchows Archiv [Cell Pathol] 12:39–50
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Ahmed, A. The ultrastructure of medullary carcinoma of the breast. Virchows Arch. A Path. Anat. and Histol. 388, 175–186 (1980). https://doi.org/10.1007/BF00430686
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DOI: https://doi.org/10.1007/BF00430686