Summary
Determination of blood group isoantigens A, B and H, was performed in benign and malignant vascular tumours of the skin and subcutaneous tissue, using the immunoperoxidase technique. No differences were noted between benign haemagioendotheliomas from children or adults: neither tumour showed the presence of antigens in intercapillary cells. Reactive conditions such as angiolymphoid hyperplasia with eosinophilia showed an intense positive reaction to blood group substances of the endothelial proliferative cells. In malignant tumours no relationship between tumour differentiation and loss of blood group isoantigens was seen. Cases of Kaposi's sarcoma did not show antigens in spindle cells or capillaries but in medium sized vessels variable preservation or loss of blood group isoantigens was found.
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References
Bergman S, Javadpour N (1978) The cell surface antigen A, B or O(H) as an indicator of malignant potential in stage A bladder carcinoma: Preliminary report. J Urol 119:49–51
Castro C, Winkelmann RK (1974) Angiolymphoid hyperplasia with eosinophilia of the skin. Cancer 34:1696–1705
Davidsohn I (1972) Early immunologic diagnosis and prognosis of carcinoma. Am J Clin Pathol 57:715–730
Davidsohn I, Ni LI (1969) Loss of isoantigens A, B and H in carcinoma of the lung. Am J Pathol 57:307–334
Davidsohn I, Kovarik S, Ni LY (1969) Isoantigens A, B and H in benign and malignant lesions of the cervix. Arch Pathol 87:306–314
Davidsohn I, Ni LY, Stejskal R (1971a) Tissue isoantigens A, B and H in carcinoma of the stomach. Arch Pathol 92:456–464
Davidsohn I, Ni LY, Stejskal R (1971b) Tissue antigens A, B and H in carcinoma of the pancreas. Cancer Res 31:1244–125)
Denk H, Tappeiner G, Davidovits A, Eckerstorfer R, Holzner JH (1974) Carcinoembryonic antigen and blood group substances in carcinomas of the stomach and colon. J Natl Cancer Inst 53:933–942
Eklund AE, Gullbring B, Lagerlof B (1963) Blood group specific substances in human gastric carcinoma. A study using fluorescent antibody technique. Acta Pathol Microbiol Scand 59:447–455
Feigl W, Denk H, Davidovits A, Holzner JH (1976) Blood group isoantigens in human benign and malignant vascular tumours. Virchows Arch [Pathol Anat] 370:323–332
Glynn LE, Holborow EJ (1959) Distribution of blood-group substances in human tissues. Br Med Bull 15:150–153
Häkkinen I (1970) A-like blood group antigen in gastric cancer cells in blood groups O or B. J Natl Cancer Inst 44:1183–1193
Holborow EH, Brown PC, Glynn LE, Hawes MD, Gresham GA, O'Brien TF, Coombs RR (1960) The distribution of the blood group A antigen in human tissues. Br J Exp Pathol 41: 430–437
Kovacs K, Corenblum B, Sirek AMT, Penz G, Ezrin C (1976) Localization of prolactin in chromophobe pituitary adenomas: study of human necropsy material by immunoperoxidase technique. J Clin Pathol 29:250–258
Rosai J, Sumner HV, Kostianovsky M, Pérez-Mesa C (1976) Angiosarcoma of the skin. A clinicopathologic and fine structural study. Hum Pathol 7:83–109
Slocombe GW, Berry CL, Swettenham KV (1980) The variability of blood group antigens in gastric carcinoma as demonstrated by the immunoperoxidase technique. Virchows Arch [Pathol Anat] 387:289–300
Stejskal R, Lill PH, Mlsna J, Davidsohn I (1978) A, B and H isoantigens in atypical oral epithelium. Cancer Immunol Immunother 3:195–199
Szulman AE (1960) The histological distribution of blood group substances A and B in man. J Exp Med 111:785–800
Weinstein RS, Alroy J, Farrow GM, Miller AW, Davidsohn I (1979) Blood group isoantigen deletion in carcinoma in situ of the urinary bladder. Cancer 43:661–668
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Berry, C.L., Amerigo, J. Blood group antigens in vascular tumours. Virchows Arch. A Path. Anat. and Histol. 388, 167–174 (1980). https://doi.org/10.1007/BF00430685
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DOI: https://doi.org/10.1007/BF00430685