Summary
In glomerulonephritis accompanying the Schönlein-Henoch syndrome (SHS) a characteristic subepithelial basement membrane change is present in 85% of cases. The subepithelial change is a reaction to subepithelial deposits and consists of a garland or dome-like new formation of thin densa lamellae. This change is much more frequent in SHS than in IgA-nephritis or idiopathic glomerulonephritis or any other systemic disease. Furthermore, subepithelial deposits (50% of cases) are nearly as frequent as subendothelial deposits (65%) and more often present than formerly assumed.
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References
Brun C, Bryld C, Fenger L, Jørgensen F (1971) Glomerular lesions in adults with the Schönlein-Henoch syndrome. A light and electron microscopy study. Acta Pathol Microbiol Scand [A] 79:569–583
Clarkson AR, Seymour AE, Thompson AJ, Haynes WDG, Chan YL, Jackson B (1977) IgAnephropathy: A syndrome of uniform morphology, diverse clinical features and uncertain progress. Clin Nephrol 8:459–471
Heaton JM, Turner DR, Cameron JS (1977) Localization of glomerular deposits in Henoch-Schönlein nephritis. Histopathol I:93–104
Kim ChK, Aikawa M, Makker SP (1979) Electron-Dense subepithelial glomerular deposits in Henoch-Schönlein Purpura syndrome. Arch Pathol Lab Med 103:595–598
Nakamoto Y, Asano Y, Dohi K, Fujioka M, Iida H, Kida H, Kibe Y, Hattori N, Takeuchi J (1978) Primary IgA glomerulonephritis and Schönlein-Henoch purpura nephritis: clinicopathological and immunohistological characteristics. Q J Med, New Series XLVII:495–516
Sinniah R, Feng PH, Chen BTM (1978) Henoch-Schönlein syndrome: a clinical and morphological study of renal biopsies. Clin Nephrol 9:219–228
Urizar RE, Michael A, Sisson S, Vernier RL (1968) Anaphylactoid purpura. II. Immunofluorescent and electron microscopic studies of the glomerular lesions. Lab Invest 19:437–450
Urizar RE, Singh JK, Muhammad T, Hines O (1978) Henoch-Schölein anaphylactoid purpura nephropathy: electron microscopic lesions mimicking acute poststreptococcal nephritis. Hum Pathol 9:223–229
Zollinger HU, Mihatsch MJ (1978) Renal pathology in biopsy. Springer, Berlin Heidelberg New York
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Zollinger, H.U., Mihatsch, M.J., Gaboardi, F. et al. Schönlein-Henoch Glomerulonephritis. Virchows Arch. A Path. Anat. and Histol. 388, 155–165 (1980). https://doi.org/10.1007/BF00430684
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DOI: https://doi.org/10.1007/BF00430684