Psychopharmacology

, Volume 50, Issue 2, pp 125–129 | Cite as

Withdrawal from ethanol: Simple quantitative behavioral tests for its evaluation

  • L. A. Pohorecky
Original Investigations

Abstract

Several behavioral manifestations were evaluated after withdrawal from ethanol in rats maintained for 6 weeks on an all-liquid diet containing ethanol. Compared with control animals (on a sucrose diet) or with animals on the chronic ethanol-containing diet, animals undergoing withdrawal displayed a greatly decreased locomotor activity in a runway, as indicated by the number of runs per trial and the time required to complete the first run. These animals also had a markedly decreased head-poke and rearing activity. All of these behavioral disturbances persisted for 3–5 days after termination of ethanol. It is suggested that behaviors such as these, which require no pretraining of animals, can be used to evaluate quantitatively the severity of withdrawal in rats.

Key words

Ethanol withdrawal Behavioral disruptions Runway activity Head-poke activity Rearing activity 

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • L. A. Pohorecky
    • 1
  1. 1.The Rockefeller UniversityNew YorkUSA

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