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Immunogenetics

, Volume 22, Issue 6, pp 637–642 | Cite as

Assignment of the gene locus for the sixth component (C6) of complement in mice to chromosome 15

  • Jun-ichiro Hayakawa
  • Hiroko Nikaido
  • Tsutomu Koizumi
Article

Abstract

A structural locus (C-6) for the sixth component of complement in mice is assigned to chromosome 15. Three-point linkage analysis indicated that the order of loci is C-6, Gpt-1, Gdc-1, and that the map distances are 25.9±4.9 between C-6 and Gpt-1, and 36.4±5.5 between C-6 and Gdc-1. Since Gdc-1 is more distal than Gpt-1, and C-6 is 26 cM away from Gpt-1, it is estimated that the C-6 is proximal to the centromere. In addition, a new C6 form found in AKR mice is described. We propose the designation C6B for it and C-6 b for the allele encoding C6B.

Keywords

Linkage Analysis Gene Locus Structural Locus Sixth Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used in this paper

IEF

isoelectric focusing

GPT

glutamic-pyruvic transaminase

GDC

L-glycerol 3-phosphate dehydrogenase

cM

centimorgan

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Jun-ichiro Hayakawa
    • 1
  • Hiroko Nikaido
    • 1
  • Tsutomu Koizumi
    • 1
  1. 1.Institute for Experimental Animals, School of MedicineKanazawa UniversityKanazawa 920Japan

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