, Volume 22, Issue 6, pp 585–591 | Cite as

The influence of graft size on the induction of immunity versus tolerance to H-Y in H-2 k strains of mice

  • R. B. Ashman


Unprimed female CBA mice do not reject large (10 mm2) syngeneic male skin grafts. However, a high proportion do reject small (4 mm2) grafts. Nevertheless, rejection does not invariably result in an anamnestic response. In some cases, the immunity induced by the rejection of a small graft was overcome, and tolerance was induced by a subsequent challenge with a large graft. This suggests that the transplantation response to minor antigens is subject to active regulation, and screening of other H-2 k strains indicates that the nature of the response (i. e., immunity or tolerance) is determined by a gene or genes mapping outside the major histocompatibility complex.


Major Histocompatibility Complex Active Regulation Skin Graft Graft Size Subsequent Challenge 
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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • R. B. Ashman
    • 1
    • 2
  1. 1.Department of Microbiology, John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia
  2. 2.Clinical Immunology Research UnitPrincess Margaret HospitalSubiacoWestern Australia

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