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Immunogenetics

, Volume 22, Issue 6, pp 585–591 | Cite as

The influence of graft size on the induction of immunity versus tolerance to H-Y in H-2 k strains of mice

  • R. B. Ashman
Article

Abstract

Unprimed female CBA mice do not reject large (10 mm2) syngeneic male skin grafts. However, a high proportion do reject small (4 mm2) grafts. Nevertheless, rejection does not invariably result in an anamnestic response. In some cases, the immunity induced by the rejection of a small graft was overcome, and tolerance was induced by a subsequent challenge with a large graft. This suggests that the transplantation response to minor antigens is subject to active regulation, and screening of other H-2 k strains indicates that the nature of the response (i. e., immunity or tolerance) is determined by a gene or genes mapping outside the major histocompatibility complex.

Keywords

Major Histocompatibility Complex Active Regulation Skin Graft Graft Size Subsequent Challenge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ashman, R. B.: Male skin grafts induce tolerance in female CBA mice. Aust. J. Exp. Biol. Med. Sci. 60: 397–399, 1982Google Scholar
  2. Ashman, R. B.: Primary immune responses to H-Y in BALB/c-H-2 k mice. Immunogenetics 18: 125–129, 1983Google Scholar
  3. Ashman, R. B.: Some characteristics of the state of tolerance induced by male skin grafts in adult female CBA mice. Transplant. Proc. 16: 946–947, 1984Google Scholar
  4. Ashman, R. B.: Tolerance induced by male skin grafts in female CBA mice can suppress the generation of H-Y specific cytotoxic T cells. Aust. J. Exp. Biol. Med. Sci. 63: 319–321, 1985Google Scholar
  5. Billingham, R. E. and Medawar, P. B.: A technique for free skin grafting in mammals. J. Exp. Biol. 28: 385–402, 1951Google Scholar
  6. Billingham, R. E., Silvers, W. K., and Wilson, D. B.: A second study on the H-Y transplantation antigen in mice. Proc. R. Soc. Lond. (Biol.) 163: 61–89, 1965Google Scholar
  7. Brenan, M. and Müllbacher, A.: Analysis of the cytotoxic T-cell response to H-Y in CBA/H mice. J. Immunol. 127: 681–685, 1981Google Scholar
  8. Calne, R. Y., Sells, R. A., Pena, J. R., Davis, D. R., Millard, P. R., Herbertson, B. M., Binns, R. M., and Davis, D. A. L.: Induction of immunological tolerance by porcine liver allografts. Nature 223: 472–476, 1969Google Scholar
  9. Coons, J. A., and Goldberg, E. H.: Rejection of male skin by splenectomised female mice. Science 200: 320–321, 1978Google Scholar
  10. Fierz, W., Brenan, M., Müllbacher, A., and Simpson, E.: Non-H-2 and H-2-linked immune response genes control the cytotoxic T-cell response to H-Y. Immunogenetics 15: 261–270, 1982Google Scholar
  11. Graff, R. J.: The relationship between immunity and tolerance. Curr. Top. Surg. Res. 3: 363–370, 1971Google Scholar
  12. Kamada, N. and Shinomiya, T.: Clonal deletion as the mechanism of abrogation of immunological memory following liver grafting in rats. Immunology 55: 85–90, 1985Google Scholar
  13. Kamada, N., Davies, H. ff. S. and Roser, B.: Reversal of transplantation immunity by liver grafting. Nature 292: 840–842, 1981Google Scholar
  14. Lappé, M. A., Graff, R. G., and Snell, G. D.: The importance of target size in the destruction of skin grafts with non-H-2 incompatibility. Transplantation 7: 372–377, 1969Google Scholar
  15. Müllbacher, A.: Natural tolerance: A model for It gene effects in the cytotoxic T-cell response to H-Y. Transplantation 32: 58–60, 1981Google Scholar
  16. Müllbacher, A. and Brenan, M.: Cytotoxic T-cell response to H-Y in ‘non-responder’ CBA mice. Nature 285: 34–36, 1980Google Scholar
  17. Simonsen, M.: On the nature and measurement of antigenic strength. Transplant. Rev. 3: 22–35, 1970Google Scholar
  18. Simpson, E.: The role of H-Y as a minor transplantation antigen. Immunol. Today 3: 97–106, 1982Google Scholar
  19. Simpson, E., Chandler, P., and Pole, D.: A model of T-cell unresponsiveness using the male specific antigen H-Y. Cell. Immunol. 62: 251–257, 1981aGoogle Scholar
  20. Simpson, E., Benjamin, D., and Chandler, P.: Nonresponsiveness to H-Y: Tolerance in H-2b mice. Transplant. Proc. 13: 1880–1883, 1981bGoogle Scholar
  21. Smith, R. N. and Powell, A. E.: The adoptive transfer of pregnancy-induced unresponsiveness to male skin grafts with thymus-dependent cells. J. Exp. Med. 146: 899–904, 1977Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • R. B. Ashman
    • 1
    • 2
  1. 1.Department of Microbiology, John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia
  2. 2.Clinical Immunology Research UnitPrincess Margaret HospitalSubiacoWestern Australia

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