Summary
The blood flow in the ciliary body vessels and ocular hydrodynamics were studied, using rheoophthalmography and tonography methods in the experiments with rabbits (17 animals, 172 experiments) and in primary open angle glaucoma (12 patients, 18 eyes) before and after the sympathicomimetic drugs instillation (phethanol, epinephrine).
It was found that the hypotensive effect of the mentioned drugs was brought about by the reduction of blood flow in the ciliary body vessels, causing in its turn the reduction of aqueous humor secretion.
Zusammenfassung
Mit Hilfe von Rheo-Ophthalmographie und Tonographie wird der Blutstrom im Ciliarkörper sowie die oculare Hydrodynamik studiert. Die Experimente wurden an 17 Kaninchen in 172 Versuchen und an 12 Patienten mit primärem Weitwinkelglaukom an 18 Augen durchgeführt vor und nach der Installation von sympathico-mimetischen Tropfen (Penthanol und Epinephrin).
Es wurde festgestellt, daß der hypotensive Effekt der erwähnten Medikamente zu einer Herabsetzung der Durchblutung in den Ciliarkörpergefäßen führt, die ihrerseits eine Reduktion von Kammerwassersekretion zur Folge hat.
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Yermakova, V.N. Investigation on some mechanisms of sympathico-mimetic drugs hypotensive action. Albrecht von Graefes Arch. Klin. Ophthalmol. 192, 331–338 (1974). https://doi.org/10.1007/BF00429993
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DOI: https://doi.org/10.1007/BF00429993