Abstract
This study investigated the mechanisms which may underly the prolactin (PRL) stimulating effects of FK 33-824, a potent enkephalin analogue. FK 33-824 (1 mg) was infused in healthy volunteers before and after pretreatment with 3 mg methysergide, a serotonin receptor blocker. All subjects showed a release of PRL after FK 33-824, which was significantly diminished after pretreatment with methysergide.
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This study was supported by the Sandoz foundation for therapeutic research
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Jungkunz, G., Nedopil, N. & Rüther, E. Methysergide decreases prolactin release after FK 33-824 [Tyr-D-Ala-Gly-MePhe-Met(o)-ol], a potent analogue of methionine enkephalin. A study in man. Psychopharmacology 83, 210–212 (1984). https://doi.org/10.1007/BF00429737
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DOI: https://doi.org/10.1007/BF00429737