Virchows Archiv A

, Volume 372, Issue 1, pp 1–9 | Cite as

Atypical quartz dust-induced pneumoconiosis in SPF rats

Aspects of the role of the lymphatic system in the pathogenesis of silicosis
  • K. G. Eden
  • H. B. von Seebach


Experimental exposure to quartz dust for 100 days (= 700h) induces in SPF rats histologic changes of the lungs, which have such striking similarities with human cases of pulmonary alveolar proteinosis that they may represent an animal model of human disease. Conventional stock rats, the standard model of experimental silicosis research, react upon the same dosage of quartz dust by the formation or an increase in size of perivascular lymphatic sheaths, in which epitheloid cell granulomas can arise. In SPF rats such granulomas can only be developed in the sparse pre-existent lymphatic tissue, mostly in hilar lymph nodes. The reaction of SPF rats opens an interesting aspect on the significance of the phenomenon of lymphatic “drainage,” as comparable reactions are only known in conventional rats following extreme dosage and in human pathology as so-called acute silicoproteinosis.

Key words

Silicosis SPF rats Conventional rats Lymphatic system Pulmonary alveolar proteinosis 


Unter experimenteller Quarzstaub-Exposition zeigen SPF-Ratten nach 100 Tagen Versuchsdauer histologische Lungenveränderungen, die bis zum Modellcharakter reichende Gemeinsamkeiten haben mit dem Bild der Alveolarproteinose der menschlichen Pathologie.

Konventionell aufgezogene Ratten, das Standard-Modell der experimentellen Silikose-Forschung, reagieren bei gleicher Dosierung mit einer Vermehrung perivasculärer Lymphgewebs-Manschetten im Lungenparenchym, in denen es zur Ausbildung von Epitheloidzell-Granulomen kommt. In SPF-Ratten treten solche Granulome nur auf im spärlichen präexistenten lymphatischen Gewebe, meist also nur in hilären Lymphknoten. Die Reaktion der SPF-Ratten eröffnet einen interessanten Aspekt auf die Bedeutung des Phänomens der lymphatischen „Lungenreinigung”. Denn vergleichbare Reaktionen kennt man bei konventionellen Ratten nur unter extremer Dosierung sowie in der menschlichen Pathologie als sogenannte akute Siliko-Proteinose.


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • K. G. Eden
    • 1
  • H. B. von Seebach
    • 1
  1. 1.Pathologisches Institut der Universität des SaarlandesHomburg/SaarGermany

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