Drug-induced decrement in spatial reversal learning in the white rat
This study investigated the effects of LSD-25, amphetamine sulfate and chlorpromazine on a simple spatial reversal learning problem in a water-filled maze. Following subcutaneous injections of 0.50 and 0.52 mg/ kg of LSD-25, albino rats were significantly handicapped in acquiring a reversed turning response. The performance of groups given 0.13 mg/kg LSD-25, 1 mg/kg chlorpromazine and 2 mg/kg amphetamine sulfate was not reliably different from a Ringer's-injected control group.
KeywordsSulfate Amphetamine Subcutaneous Injection Chlorpromazine Learning Problem
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- Hamilton, C. L., and C. Wilpizeski: Effects of LSD-25 on food intake in the rat. Proc. Soc. exp. Biol. (N.Y.) 108, 319–321 (1961).Google Scholar
- Harris, S. C., A. C. Ivy, and L. M. Searle: The mechanism of amphetamine induced loss of weight. J. Amer. med. Ass. 134, 1468–1476 (1947).Google Scholar
- Kety, S. S.: The pharmacology of psychotomimetic and psychotherapeutic drugs. Ann. N. Y. Acad. Sci. 66, 417–480 (1957).Google Scholar
- Mosteller, F., and R. R. Bush: Selected quantitative techniques. In G. Lindzey (Ed.): Handbook of social psychology. Cambridge, Mass.: Addison-Wesley 1954.Google Scholar
- Winter, C. A., and L. Flataker: Effects of lysergic acid diethylamide upon performance of trained rats. Proc. Soc. exp. Biol. (N. Y.) 92, 285–289 (1956).Google Scholar