Summary
A new test for physical dependence (addition liability) of drugs in morphine-dependent rats is described. It depends upon the abolition of spontaneous withdrawal writhing by drugs possessing morphine-like addiction liability. A quantitative estimation of addictive potency of narcotic analgesics is given and some evidence for the possible mechanism of this phenomenon of withdrawal writhing is presented.
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Buckett, W.R. A new test for morphine-like physical dependence (addiction liability) in rats. Psychopharmacologia 6, 410–416 (1964). https://doi.org/10.1007/BF00429568
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DOI: https://doi.org/10.1007/BF00429568