Abstract
The effects of alpha-methyl-p-tyrosine (aMpT) on the initial liability to consume oral morphine solution and on withdrawal following cessation of passive morphine administration were assessed. aMpT depressed consumption of oral morphine solution if aMpT was administered throughout a nine day period of morphine intake; when aMpT administration was stopped a day prior to presentation of morphine solution, subsequent intakte of morphine was enhanced. Following cessation of passive morphine administration, aMpT was found to ameliorate withdrawal-induced weight loss; this effect occurred to a similar extent regardless of whether aMpT was administered only during the first withdrawal day, only on days of morphine administration or during both periods of morphine administration and withdrawal. These results implicate an important role of catecholamines in addiction and dependence to morphine.
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References
Akera, T., Brody, T. M.: The addiction cycle to narcotics in the rat and its relation to catecholamines. Biochem. Pharmacol. 17, 675–688 (1968)
Clouet, D. H., Ratner, M.: Catecholamine biosynthesis in brains of rats treated with morphine. Science 168, 854–856 (1970)
Dairman, W., Christenson, J. G., Udenfriend, S.: Changes in tyrosine hydroxylase and dopa decarboxylase induced by pharmacological agents. Pharmacol. Rev. 24, 269–289 (1972)
Davis, W. M., Babbini, M., Khalsa, J. H.: Antagonism by alpha-methyltyrosine of morphine induced motility in non-tolerant and tolerant rats. Res. Comm. Chem. Path. Pharm. 4, 267–279 (1972)
Enna, S. J., Dorris, R. L., Shore, P. A.: Specific inhibition by ox-methyltyrosine of amphetamine-induced amine release from brain. J. Pharmacol. exp. Ther. 184, 576–582 (1973)
Glick, S. D., Greenstein, S., Zimmerberg, B.: Facilitation of recovery by α-methyl-p-tyrosine after lateral hypothalamic damage. Science 177, 534–535 (1972)
Goode, P. G.: An implanted reservoir of morphine solution for rapid induction of physical dependence in rats. Brit. J. Pharmacol. 41, 558–566 (1971)
Joy, R. T., Emma, C. P., Mayer, J.: New rat feeding jar: use in study of relationships of food intake and body weight. J. appl. Physiol. 23, 289–290 (1967)
Menon, M. K., Dandiya, P. C., Bapna, S. J.: Modification of the effect of some central stimulants in mice pretreated with α-methyl-p-tyrosine. Psychopharmacologia (Berl.) 10, 437–444 (1967)
Pozuelo, J., Kerr, F. W. L.: Suppression of craving and other signs of dependence in morphine-addicted monkeys by administration of alpha-methyl-paratyrosine. Proc. Mayo Clin. 47, 621–628 (1972)
Rosenman, S. J., Smith, C. B.: 14C-catecholamine synthesis in mouse brain during morphine withdrawal. Nature (Lond.) 240, 153–155 (1972)
Smith, C. B., Sheldon, M. I., Bednarczyk, J. H., Villarreal, J. E.: Morphine-induced increases in the incorporation of 14C-norepinephrine in the mouse brain: antagonism by nalozone and tolerance. J. Pharmacol. exp. Ther. 180, 547–557 (1972)
Way, E. L., Shen, F. H.: Catecholamines and 5-hydroxytryptamine. In Narcotic Drugs, ed. D. H. Clouet, pp. 229–253. New York: Plenum Press 1971
Ziegler, H., Basso, P. D., Longo, V. G.: Influence of 6-hydroxydopamine and of α-methyl-p-tyrosine on the effects of some centrally acting agents. Physiol. Behav. 8, 391–396 (1972)
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This research was supported by grants DA00535 from NIMH, U-2177 from the Health Research Council of the City of N.Y. and by NIMH Research Scientist Development Award (Type 2) DA70082 to S. D. Glick. The authors thank Richard Marsanico for indispensable technical assistance.
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Glick, S.D., Zimmerberg, B. & Charap, A.D. Effects of α-methyl-p-tyrosine on morphine dependence. Psychopharmacologia 32, 365–371 (1973). https://doi.org/10.1007/BF00429473
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DOI: https://doi.org/10.1007/BF00429473