Abstract
Rats were trained to choose between the side compartments of a three-chambered shock-escape apparatus according to whether they were injected with nicotine or saline. Half of the rats learned to discriminate between 0.4 mg/kg nicotine and saline administered subcutaneously, whereas the other half learned to differentiate between 644 ng nicotine or saline administered intraventricularly. The rats trained by the subcutaneous route of administration had the ability to discriminate between nicotine and saline given intraventricularly and the rats trained by the intraventricular route could differentiate when the two substances were injected subcutaneously. This transfer of state-dependent control of discriminative behaviour between subcutaneously and intraventricularly administered nicotine and saline is presented as evidence for the central origin of the nicotine-produced interoceptive cue.
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This work supported by a grant from the American Medical Association Education and Research Foundation.
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Schechter, M.D. Transfer of state-dependent control of discriminative behaviour between subcutaneously and intraventricularly administered nicotine and saline. Psychopharmacologia 32, 327–335 (1973). https://doi.org/10.1007/BF00429468
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DOI: https://doi.org/10.1007/BF00429468