Abstract
Daily food intake, masticatory activity and reticular movements were studied in sheep before and after intracerebroventricular injections of various drugs. Pour animals received nialamide (1 mg twice daily for 21 days) and four others received 6-hydroxydopamine (one injection of 4 mg). Nialamide increased food intake in all the subjects. It increased rumination time and inhibited the oral reflex of the reticulum in half of the subjects. 6-hydroxydopamine reduced food intake and rumination time and accelerated the rhythm of reticular contractions during rest and rumination. The effects of nialamide and 6-hydroxydopamine on the cerebral concentration of serotonin, noradrenaline and dopamine have been extensively documented over the past few years. Modifications of food intake, rumination and reticular motility can be explained by variations in the cerebral concentration of noradrenaline and/or dopamine. These two amines (or one of them) could be implicated in the control of rumination and could act on central mechanisms monitoring forestomach motility.
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Croze, S., Bost, J. Comportement alimentaire du mouton effets de la nialamide et de la 6-hydroxydopamine. Psychopharmacologia 40, 259–268 (1974). https://doi.org/10.1007/BF00429420
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DOI: https://doi.org/10.1007/BF00429420