, Volume 27, Issue 4, pp 359–366 | Cite as

The role of social isolation and sex in determining effects of chlordiazepoxide and methylphenidate on exploratory behaviour

  • R. N. Hughes
  • Lesley A. Syme
Animal Studies


Effects of two doses each of chlordiazepoxide and methylphenidate on exploration, locomotion and rearing were observed in isolated and grouped male and female rats. Sex of the animals determined the effects of both drugs on rearing, and of chlordiazepoxide on preferences for the novel half of an exploration box. Drug administration seemed to abolish initial sex differences on the former response. Locomotion of isolated and grouped animals was also differentially affected by chlordiazepoxide. These findings emphasised the need to take genetic and environmental factors into account when considering the effects of psychotropic drugs on exploratory behaviour.

Key words

Isolation Sex Differences Chlordiazepoxide Methylphenidate Exploration Locomotion Rearing 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • R. N. Hughes
    • 1
  • Lesley A. Syme
    • 1
  1. 1.Department of PsychologyUniversity of CanterburyNew Zealand

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