Abstract
The effects of δ 9-tetrahydrocannabinol upon rat blood pressure were studied in control rats and in rats subjected to repeated immobilization stress over seven days. The immobilization stress was associated with a significant blood pressure increase in animals not receiving δ 9-THC. δ 9-THC resulted in a significant lowering of blood pressure in non-immobilized rats and blocked the appearance of hypertension in immobilized rats. These data support previous suggestions that THC compounds might be useful in an approach to the therapy of hypertension.
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Williams, R.B., Ng, L.K.Y., Lamprecht, F. et al. Δ9-Tetrahydrocannabinol: A hypotensive effect in rats. Psychopharmacologia 28, 269–274 (1973). https://doi.org/10.1007/BF00429307
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DOI: https://doi.org/10.1007/BF00429307