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Effects of Δ1(2)-tetrahydrocannabinol on copulation in the male rat

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The mating behavior of 15 male rats was measured after treatment with δ 1(2)-tetrahydrocannabinol (THC) and propylene glycol (vehicle). Administration of either 2 mg per kg or 3 mg per kg body weight of THC was followed by significant increases in latency to the first mount, latency to ejaculation, and latency to the first mount following ejaculation. No significant changes were found in the number of intromissions or mounts. The deterioration in sexual performance is interpreted as reflecting a decreased motivation to copulate under the influence of the drug.

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Merari, A., Barak, A. & Plaves, M. Effects of Δ1(2)-tetrahydrocannabinol on copulation in the male rat. Psychopharmacologia 28, 243–246 (1973).

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