State dependent learning produced by post trial intrathoracic administration of sodium pentobarbital
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The state dependent learning paradigm was used with a one-trial, passive avoidance task. Forty male rats were equally distributed among four groups: One group received intrathoracic injections of sodium pentobarbital immediately after the acquisition trial and immediately before the retention test trial; a second group received equivalent injections of 0.9% saline; a third group was drugged after acquisition and given saline prior to retention testing and the fourth group was given saline after acquisition and drug prior to retention testing. All groups showed increased latencies on the retention trial but marked group differences in retention test latencies indicate that there was significantly more retention of training when drug states were the same during the memory storage interval and the memory retrieval interval. Intrathoracic injection proved to be a practical substitute for intravenous injection in assuring rapid onset of drug effect.
Key wordsState Dependent Learning Memory Consolidation Sodium Pentobarbital Drug Dissociation Retrograde Amnesia
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- Chute, D. L., Wright, D. C.: Retrograde state dependent learning. Science (in press) (1973).Google Scholar
- McGaugh, J. L., Herz, M. J.: Memory consolidation. San Francisco: Albion 1972.Google Scholar
- Otis, L. S.: Dissociation and recovery of a response learned under the influence of chlorpromazine or saline. Science 143, 1347–1348 (1964).Google Scholar
- Overton, D. A.: Dissociated learning in drug states (State-dependent learning). In: Psychopharmacology, a review of progress, 1957–1967. D. H. Efron, J. O. Cole, J. Levine, and J. R. Wittenborn, eds., pp. 918–930. Public Health Service Publication No. 1836, U.S. Government Printing Office, Washington 1968.Google Scholar
- Overton, D. A.: State-dependent or dissociated learning produced with pentobarbital (revised with commentary). In: Behavioral analysis of drug action. J. A. Harvey, ed., pp. 56–83. Glenview, Illinois: Foresman & Co. 1971.Google Scholar
- Siegel, S.: Nonparametric statistics for the behavioral sciences. New York: McGraw-Hill 1956.Google Scholar