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Psychopharmacologia

, Volume 31, Issue 1, pp 35–48 | Cite as

Some agonistic actions of the morphine antagonist levallorphan on behavior and brain monoamines in the rat

  • Harriett R. Steinert
  • Stephen G. Holtzman
  • Robert E. Jewett
Animal Studies

Abstract

The effects of levallorphan, a narcotic-antagonist analgesic, were studied on locomotor activity, operant behavior (continuous avoidance schedule), and brain monoamine content in the rat. Levallorphan produced an increase in locomotor activity and in the rate of avoidance responding. Brain norepinephrine was significantly decreased 1 h after 256 mg/kg of levallorphan. Brain dopamine (DA) levels were lowered by 64 and 256 mg/kg of levallorphan. There was no effect on brain serotonin levels. The stimulant effects of levallorphan on operant behavior were blocked by simultaneous administration of naloxone. A clear antagonism of the effects of levallorphan on locomotor activity by naloxone could be demonstrated for low doses of levallorphan but not for doses above 16 mg/kg. Naloxone also failed to prevent the depletion of brain catecholamines produced by levallorphan. Naloxone alone had no consistent effect on either of the behaviors under observation or on brain monoamine content. These findings indicate that levallorphan is a stimulant of behavior in the rat, and that the stimulant action is mediated by at least two mechanisms: one which is blocked by naloxone, and one which is not. Furthermore, it is suggested that the rat should be considered as a possible animal model in which to study the agonistic properties of certain narcotic-antagonist analgesics on behavior.

Key words

Naloxone Levallorphan Narcotic Antagonist Locomotor Activity Operant Behavior 

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Harriett R. Steinert
    • 1
  • Stephen G. Holtzman
    • 1
  • Robert E. Jewett
    • 1
  1. 1.Department of PharmacologyEmory UniversityAtlanta

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