, Volume 43, Issue 3, pp 267–269 | Cite as

Behavioural effects of thymoleptics in vervet monkeys (Cercopithecus aethiops)

  • B. Kjellberg
  • A. Randrup
Animal Studies


Desmethylimipramine (DMI) exerts diverse quantitative effects on the gross behaviour of monkeys. Excitatory as well as sedative effects were observed, which varied according to the general animal temperament. Results resembling those obtained with DMI were observed using chlorimipramine and iprindole, although the effects of iprindole were less marked. Chlorimipramine also produced immobilization and postural change.

The results are discussed in relation to behavioural effects of thymoleptics in humans, and the use of monkeys in preclinical testing of thymoleptic drugs is suggested.

Key words

Desmethylimipramine Chlorimipramine Iprindole Monkeys Excitation Sedation 


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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • B. Kjellberg
    • 1
    • 2
  • A. Randrup
    • 1
    • 2
  1. 1.Pharmacological DepartmentAB FerrosanMalmöSweden
  2. 2.Dept. ESt. Hans HospitalRoskildeDenmark

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