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Probenecid: Dosage, levels in plasma and cerebrospinal fluid (CSF) and influence upon CSF levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the rabbit

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Abstract

Probenecid retards the efflux of acid monoamine metabolites from the brain tissue and CSF to the blood. The probenecid-induced accumulation of these metabolites is held to be indicative of the turnover rate of the corresponding amines. Although the penetration of probenecid into the CSF does not proceed at a constant rate, Korf et al. (1972) and Sjöstrom (1972) have shown a correlation between CSF levels of probenecid and that of HVA and 5-HIAA. In this study an attempt was made to establish the relationship between doses of probenecid and levels of this compound in plasma and CSF; between levels in plasma and CSF; and between CSF levels of probenecid and of HVA and 5-HIAA. This study was performed in a homogeneous group of laboratory rabbits.

All correlations proved to be significant. The implications of these results for studies using the probenecid technique are discussed.

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  1. Netherlands Central Institute for Brain Research, Amsterdam

    J. P. Muizelaar & J. I. Oberink

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  1. J. P. Muizelaar
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  2. J. I. Oberink
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Muizelaar, J.P., Oberink, J.I. Probenecid: Dosage, levels in plasma and cerebrospinal fluid (CSF) and influence upon CSF levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in the rabbit. Psychopharmacologia 43, 223–227 (1975). https://doi.org/10.1007/BF00429254

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  • DOI: https://doi.org/10.1007/BF00429254

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