Abstract
Serial plasma clozapine levels and serum prolactin levels were determined in two schizophrenic patients receiving clozapine, a novel antipsychotic drug. Despite marked therapeutic response and substantial clozapine blood levels, prolactin levels obtained 11–12 h after the last oral dose were unaffected or only minimally elevated. This confirms previous evidence of clozapine's unusal characteristics.
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Kane, J.M., Cooper, T.B., Sachar, E.J. et al. Clozapine: Plasma levels and prolactin response. Psychopharmacology 73, 184–187 (1981). https://doi.org/10.1007/BF00429215
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DOI: https://doi.org/10.1007/BF00429215