Abstract
Within groups of three adult male mice the acute and subchronic effects of hashish extract (20 mg δ 9 - THC/kg) on social dominance, food dominance, and sexual interactions with a female were investigated. An initial drug treatment of only the dominant male weakened his social position, but dominance was regained after treatment 2 or 3. In contrast, a persistent change in dominance was found when only the male which was dominant in the feeding test was treated with the extract. Simultaneous drug treatment of all three males did not affect the social dominance relationship but resulted in a reversible change in food dominance. The original feeding order was reestablished after drug treatment 3. Upon meeting an estrous female, no male of the group was distinctly dominant in mating. After treatment 1 was given to all members of the group, all types of behavior were impaired and total activity was significantly reduced. After treatment 2, animals showed tolerance to the sedative effects, and after treatment 3, sexual behavior was even more frequent in drugged animals than in controls. The results are discussed in relation to a possible dependence of behavioral drug effects and tolerance development on the experimental situation.
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Present Address: I.C.I.P.E. Research Centre, PO Box 30772, Nairobi, Kenya
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Sieber, B., Frischknecht, HR. & Waser, P.G. Behavioral effects of hashish in mice. Psychopharmacology 73, 142–146 (1981). https://doi.org/10.1007/BF00429205
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DOI: https://doi.org/10.1007/BF00429205