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Modification of Δ9-THC-actions by cannabinol and cannabidiol in the rat

Abstract

Cannabinol (CBN) and Cannabidiol (CBD) were tested in several test procedures known to be altered by δ 9-tetrahydrocannabinol (THC) or crude cannabis preparations. They were inactive in doses up to 80 mg/kg in tests on animal motility, food and water intake, body temperature and catalepsy. In contrast, CBD enhanced the hexobarbitone “sleeping time” more pronounced than δ 9-THC whereas CBN increased the “sleeping time” only slightly. When administered in combination CBD prolonged all actions of THC, whereas CBN selectively blocked the effect of THC on hexobarbitone “sleeping time”. The enhancement by CBD is best explained by an inhibition of THC-metabolism.

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Supported in part by a research grant of the Bundesminister für Jugend, Familie und Gesundheit.

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Fernandes, M., Schabarek, A., Coper, H. et al. Modification of Δ9-THC-actions by cannabinol and cannabidiol in the rat. Psychopharmacologia 38, 329–338 (1974). https://doi.org/10.1007/BF00429130

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  • DOI: https://doi.org/10.1007/BF00429130

Key words

  • δ 9-Tetrahydrocannabinol
  • Cannabinol
  • Cannabidiol
  • Interaction
  • Hexobarbitone
  • Motility
  • Food Intake
  • Water Intake
  • Body Temperature
  • Catalepsy