The effects of long term administration of psychotropic drugs on human sleep: I. Methodology and the effects of placebo
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These six papers present the effects on human sleep of long-term administration of reserpine (0.50 mg/day), amitriptyline (50 mg/day), chlorpromazine (50 mg/day), chloral hydrate (500 mg/day), and chlordiazepoxide (50 mg/day).
This initial paper describes in detail the methodology of the entire study which involves six 60-day drug periods for each subject completing the protocol-one period on each of the five drugs and one period on placebo, in a balanced design. Measures of laboratory sleep, home sleep, and mood were obtained throughout the study.
Comparisons between the long placebo-only period of this study and the more usual “baseline” period-laboratory nights 4-6-revealed a significantly higher total desynchronized sleep time (D-time) and D-time per cent in the placebo period. Other variables were not significantly different. Some clear changes over time within the long placebo period are also described.
Key wordsSleep Drugs Psychotropic Drugs Placebo
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