Abstract
Various minor tranquilizers (benzodiazepines, barbiturates and meprobamate) induced an increase in the food intake of rats or mice. Drugs were injected i.p. 30 min before testing and the amount of food consumed during 30 min was recorded. The enhanced food consumption occurred when the animals were in a novel situation, in a situation which they had previously experienced, or in their home cage, in which they were used to eating in the daytime within 30 min. Studies with two benzodiazepines showed this effect to be maximal between 10 to 30 min after injection and to disappear 4 hrs after injection. Moreover, minor tranquilizers reduce the latency before eating of rats and mice tested in a new situation. These results and the observation of anti-anxiety drugs-induced hyperphagia in satiated animals suggest that:
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1.
The enhanced food consumption of a non familiar food in a novel situation induced by the minor tranquilizers could hardly be related only to their anti-anxiety action.
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2.
The existence of some inhibitory controls (endogenous satiety in daytime or satiety after recent absorption) is not essential for the action of the minor tranquilizers.
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3.
An increased motivation and a disruption in the food related behavior could possibly be an explanation for all the observed effects.
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Références
Bainbridge, J. G.: The effect of psychotropic drugs on food reinforced behaviour and on food consumption. Psychopharmacologia (Bed.) 12, 204–213 (1968)
Barnett, S. A.: Experiments on “neophobia” in wild and laboratory rats. Brit. J. Psychol. 49, 195–201 (1958)
Boissier, J. R., Zebrowska-Lupina, J., Simon, P.: Profil psychopharmacologique du Prazépam. Arch. int. Pharmacodyn. 196, 330–344 (1972)
Booth, D. A., Nicholls, J.: Behavioral specificity of chloralose-induced feeding in the rat. Psychopharmacologia (Berl.) 39, 145–150 (1974)
Borella, L. E., Paquette, R., Herr, F.: The effect of some CNS depressants on the hypermotility and anorexia induced by amphetamine in rats. Canad. J. Physiol. Pharmacol. 47, 841–847 (1969)
Cappell, H., Le Blanc, A. E.: Punishment of saccharin drinking by amphetamine in rats and its reversal by chlordiazepoxide. J. comp. physiol. Psychol. 85, 97–104 (1973)
Christmas, A. J., Maxwell, D. R.: A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats. Neuropharmacology 9, 17–29 (1970)
Feldberg, W. A.: A physiological approach to the problem of general anesthesia and of loss of consciousness. Brit. med. J. 2, 771–782 (1959)
Hall, C. S.: Emotional behavior in the rat: I-defecation and urination as measures of individual differences in emotionality. J. comp. Psychol. 18, 385–403 (1934)
Itoh, H., Takaori, S.: Effects of psychotropic agents on the exploratory behavior of rats in a Y-shaped box. Jap. J. Pharmacol. 18, 344–352 (1968)
Jennings, W. A., McCutcheon, L. E.: Novel food and novel running wheels: conditions for inhibition of sucrose intake in rats. J. comp. physiol. Psychol. 87, 100–105 (1974)
Mabel, J. A., Baile, C. A., Mayer, J.: Hyperphagia induced by ventricular pressure and pentobarbitone in normal and hypothalamic obese rats. Lancet 1966 II, 472–473
Margules, D. L., Stein, L.: Neuroleptic vs tranquilizers: Evidence from animals of mode and site of action. In: Neuropsychopharmacology, H. Brill, ed. Amsterdam: Excerpta Medica 5, 108–120 (1967)
Mulas, A., Crabai, E., Pepeu, G.: The influence of repeated experience on the effects of scopolamine and of amphetamine on exploratory behaviour in the rat. Pharmacol. Res. Commun. 2, 169–176 (1970)
Nachman, M., Ashe, J. H.: Effects of basolateral amygdala lesions on neophobia, learned taste aversions and sodium appetite in rats. J. comp. physiol. Psychol. 87, 622–643 (1974)
Poschel, B. P. H.: A simple and specific screen for benzodiazepine-like drugs. Psychopharmacologia (Berl.) 19, 193–198 (1971)
Poschel, B. P. H., McCarthy, D. A., Chen, G., Ensor, C. R.: Pyrazapon (CI-683): A new antianxiety agent. Psychopharmacologia (Berl.) 35, 257–271 (1974)
Randall, L. O., Schallek, W., Heise, G. A., Keith, E. F., Bagdon, R. E.: The psychosedative properties of methaminodiazepoxide. J. Pharmacol. exp. Ther. 129, 163–171 (1960)
Seoane, J. R., Baile, C. A.: Feeding behavior in sheep as related to the hypnotic activities of barbiturates injected into the third ventricule. Pharmacol. Biochem. Behav. 1, 47–53 (1973)
Soubrié, P., Simon, P., Boissier, J. R.: Newer or more operational models for studying antianxiety drugs in animals. In: Neuropsychopharmacology. Boissier et al., ed. Exc. Med. Amsterdam 9, 720–728 (1975a)
Soubrié, P., Thiebot, M. H., Simon, P., Boissier, J. R.: (résultats non publiés) (1975b)
Spengler, J., Waser, P.: Der Einflu\ verschiedener Pharmaka auf den Futterkonsum von Albino-Ratten im akuten Versuch. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 237, 171–185 (1959)
Stein, L.: Chemistry of reward and punishment. In: Psychopharmacology. A review of progress, 1957-1967, D. H. Efron, ed., pp. 105–123. Washington: U.S. Gov. Printing Office 1968
Stephens, R. J.: The influence of mild stress on food consumption in untrained mice and the effect of drugs. Brit. J. Pharmacol. 47, 145 (1973)
Wedeking, P. W.: Schedule-dependent differences among antianxiety drugs. Pharmacol. Biochem. Behav. 2, 465–472 (1974)
Wise, R. A., Dawson, V.: Diazepam-induced eating and lever pressing for food in satiated rats. J. comp. physiol. Psychol. 86, 930–941 (1974)
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Soubrié, P., Kulkarni, S., Simon, P. et al. Effets des anxiolytiques sur la prise de nourriture de rats et de souris placés en situation nouvelle ou familière. Psychopharmacologia 45, 203–210 (1975). https://doi.org/10.1007/BF00429062
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DOI: https://doi.org/10.1007/BF00429062