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Psychopharmacologia

, Volume 45, Issue 2, pp 177–181 | Cite as

The effect of caffeine on human performance, alone and in combination with ethanol

  • H. M. Franks
  • H. Hagedorn
  • V. R. Hensley
  • W. J. Hensley
  • G. A. Starmer
Human Pharmacology

Abstract

The effect of caffeine (300 mg/70 kg) on cognitive, perceptual and motor functions was investigated both alone and in combination with ethanol (0.75 g/kg) in 68 healthy student volunteers of both sexes. A test battery consisting of standing steadiness, simple and complex reaction time, manual dexterity, numerical reasoning, perceptual speed and verbal fluency was used. Placebos for both drugs were included. Caffeine was administered in decaffeinated coffee immediately after finishing drinking the alcoholic beverage. A peak plasma ethanol concentration of 92 ± 4 mg/100 ml occurred at 40 min which was not modified by caffeine. Caffeine did not antagonise the ethanol-induced decrement in performance except in the reaction time tests. Caffeine alone caused a significant increase in body sway at 40 min.

Key words

Antagonism Caffeine Ethanol Human performance 

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • H. M. Franks
    • 1
  • H. Hagedorn
    • 2
  • V. R. Hensley
    • 2
  • W. J. Hensley
    • 3
  • G. A. Starmer
    • 1
  1. 1.Departments of PharmacologyUniversity of Sydney
  2. 2.Departments of PsychologyUniversity of Sydney
  3. 3.Department of BiochemistryRoyal Prince Alfred HospitalCamperdown

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