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Effect of whole body vibration on the rat brain content of serotonin and plasma corticosterone

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Summary

To investigate the effects of whole body vibration on the central nervous system, rats were exposed to various whole body vibrations and changes in whole brain levels of Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were then determined. Changes in plasma corticosterone levels were also determined and related to the changes in the whole brain levels of 5-HT and 5-HIAA. The dose-related changes in the 5-HT and 5-HIAA levels were observed as acceleration increased from 0.4G to 5.0G. Changes in vibration frequency also affected the 5-HT and 5-HIAA levels of brain: they were significantly elevated at a frequency of 20 Hz (P<0.05). Plasma corticosterone levels increased as acceleration increased from 0.4G to 5.0G. As the vibration frequency was changed from 5 Hz to 30 Hz, plasma corticosterone levels also rose significantly (P<0.05) but the extent of elevation was approximately the same at each frequency. The correlation between brain 5-HT and plasma corticosterone levels with increasing acceleration (r=0.93, P<0.01) was significant.

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Authors and Affiliations

  1. Department of Public Health, School of Medicine, Kanazawa University, 13-1 Takara-machi, 920, Kanazawa, Japan

    Makoto Ariizumi & Akira Okada

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  1. Makoto Ariizumi
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  2. Akira Okada
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Ariizumi, M., Okada, A. Effect of whole body vibration on the rat brain content of serotonin and plasma corticosterone. Europ. J. Appl. Physiol. 52, 15–19 (1983). https://doi.org/10.1007/BF00429019

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  • DOI: https://doi.org/10.1007/BF00429019

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