Psychopharmacology

, Volume 81, Issue 2, pp 170–176 | Cite as

Differential effects of dopaminergic agonists on food-reinforced operant behavior in the long-tailed macaque (Macaca fascicularis)

  • David J. Dooley
  • Douglas M. Bowden
Original Investigations
  • 13 Downloads

Abstract

Dopaminergic involvement in the regulation of operant behavior was examined by monitoring responding after administration of different dopaminergic agonists. A chain schedule of reinforcement was used to classify the effects of these agonists in long-tailed macaques (Macaca fascicularis). The schedule included the following: (1) a 30-s time-out period; (2) a clock-cued 30-s period of differential reinforcement of zero-response rate; (3) a time-in period whose duration depended, on response latency; (4) a 2-s reinforcement period in which applesauce was delivered. This cycling schedule maintained a low operant rate and was sensitive to both inhibition (decreases) and excitation (increases) of responding. IV injection of the dopaminergic agonists resulted in the following two basic effects: (1) d-amphetamine and amfonelic acid disrupted performance by response inhibition, which was shown not to be attributable to anorexia; (2) apomorphine and bromocriptine disrupted performance by response excitation. Both effects were reduced by pretreatment with trifluperidol, a dopaminergic antagonist. The results, indicating that dopaminergic systems mediate disruption of food-reinforced operant behavior by altering the frequency of responding, are interpreted in terms of the known neuropharmacological actions of the agonists.

Key words

Dopaminergic agonists d-Amphetamine Amlonelic acid Apomorphine Bromocriptine Operant behavior Monkey 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • David J. Dooley
    • 1
  • Douglas M. Bowden
    • 1
  1. 1.Department of Pharmacology, School of Medicine and Regional Primate Research CenterUniversity of WashingtonSeattleUSA

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