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Psychopharmacologia

, Volume 41, Issue 3, pp 245–247 | Cite as

The relation between cerebral serotonin levels and conditioned behaviour in the rat following the administration of LSD-25 and UML

  • Michele Torre
  • Eugenio Torre
  • Filippo Bogetto
Animal Studies

Abstract

Successive daily injections of LSD-25 and UML (1-methyl-d-lysergic acid butanolamide) caused progressive depression of brain 5-HT levels in the rat. On the fourth day, the decrease was significant with respect to the highly significant fall observed after a single administration, whereas it had been shown earlier that conditioned behaviour is no longer affected by LSD-25 after 3 days and that simultaneous administration of a single dose of LSD-25 and UML is equally ineffective in this respect. Its depression of 5-HT levels, however, has now been shown to be equal to that of LSD-25 alone at doses that influence conditioned behaviour. The findings indicate that changes in such behaviour are not dependent on brain 5-HT levels and that no link exists between such levels and the psychotomimetic effect of LSD-25 in man.

Key words

LSD-25 UML Acute Chronic Behaviour 5-HT Brain Rat 

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References

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • Michele Torre
    • 1
  • Eugenio Torre
    • 1
  • Filippo Bogetto
    • 1
  1. 1.Department of Psychiatry and PsychopharmacologyUniversity of TurinItaly

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