Abstract
Fluorescence microscopy of rat brains after administration of (+)-erythro-DOPS has been studied.
(+)-erythro-DOPS induced an increase of brain NE part of which was formed in the capillary walls.
The slight diminution of this increase when (+)-erythro-DOPS was administered after inhibition of peripheral decarboxylase, might result from the algebraic sum of two inversely acting processes: suppression of NE synthesis in the capillary walls and enhancement of parenchymatous NE in some brain areas.
(+)-erythro-DOPS enters different brain structures non specifically and NE is formed in DA and 5-HT systems, displacing the amines especially at the terminals; the NE formed by (+)-erythro-DOPS in NE systems should be rapidly catabolised.
Possible pharmacological effects of (+)-erythro-DOPS administration involve consideration of the lack of topical specificity of NE formation; the displacement of 5-HT and DA; and the fact (+)-erythro-DOPS produces (+)-NE, and not naturally occurring NE.
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Constantinidis, J., Geissbuhler, F., Gaillard, J.M. et al. Formation de noradrénaline dans le cerveau du rat après administration de (+)-erythro-3,4-dihydroxyphenylsérine. Psychopharmacologia 41, 201–209 (1975). https://doi.org/10.1007/BF00428925
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DOI: https://doi.org/10.1007/BF00428925