Skip to main content
Log in

Intragastric self-administration of morphine as a measure of addiction

  • Published:
Psychopharmacologia Aims and scope Submit manuscript

Abstract

In experiments carried out on male albino rats it was found that instrumental conditioning reinforced with direct intragastric infusion of morphine could be used for the investigation of addiction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Beach, H. D.: Morphine addiction in rats. Canad. J. Psychol. 11, 104–112 (1957)

    Google Scholar 

  • Cytawa, J., Luszawska, D., Schoenborn, R., Zajac, M.: Lack of instrumental conditioning with intragastric reinforcement in normal experimental procedure. Acta neurobiol. exp. 32, 767–772 (1972)

    Google Scholar 

  • Deneau, G., Yanagita, T., Seevers, M. H.: Self-administration of psychoactive substances by the monkey. A measure of psychological dependence. Psychopharmacologia (Berl.) 16, 30–48 (1969)

    Google Scholar 

  • Epstein, A. N.: Water intake without act of drinking. Science 131, 497–498 (1960)

    Google Scholar 

  • Epstein, A. N., Teitelbaum, P.: Regulation of food intake in the absence of taste, smell and other oropharingeal sensations. J. comp. physiol. Psychol. 55, 753–759 (1962)

    Google Scholar 

  • Götestam, K. G.: Intragastric self-administration of medazepam in rats. Psychopharmacologia (Berl.) 28, 87–94 (1973)

    Google Scholar 

  • Kumar, R., Steinberg, H., Stolerman, I. P.: Inducing a preference for morphine in rats without premedication. Nature (Lond.) 218, 564–565 (1968)

    Google Scholar 

  • Kumar, R., Steinberg, H., Stolerman, I. P.: How rats become dependent on morphine in the course of relieving another need. In: Scientific basis of drug dependence. H. Steinberg, Ed., pp. 209–220. London: Churchill 1969

    Google Scholar 

  • Nichols, J. R.: How opiates change behavior. Sci. Amer. 212, 80–88 (1965)

    Google Scholar 

  • Nichols, J. R., Davis, W. M.: Drug addiction II. Variation of addiction. J. Amer. pharm. Ass. 48, 259–262 (1959)

    Google Scholar 

  • Nichols, J. R., Headlee, C. P., Coppock, H. W.: Drug addiction I. Addiction by escape training. J. Amer. pharm. Ass. 45, 788–791 (1956)

    Google Scholar 

  • Nichols, J. R., Hsiao, S.: Addiction liability of albino rats. Breeding for quantitative differences of morphine drinking. Science 157, 561–563 (1967)

    Google Scholar 

  • Risner, M. E., Khavari, K. A.: Morphine dependence in rats produced after five days of ingestion. Psychopharmacologia (Berl.) 28, 51–62 (1973)

    Google Scholar 

  • Schuster, C. R., Thompson, T.: Self-administration of and behavioral dependence on drugs. Ann. Rev. Pharmacol. 9, 483–502 (1969)

    Google Scholar 

  • Stolerman, I. P., Kumar, R.: Preferences for morphine in rats: validation of an experimental model for dependence. Psychopharmacologia (Berl.) 17, 137–150 (1970)

    Google Scholar 

  • Thompson, T., Schuster, C. R.: Morphine self-administration, food reinforced, and avoidance behaviors in rhesus monkeys. Psychopharmacologia (Berl.) 5, 87–94 (1964)

    Google Scholar 

  • Weeks, J. R.: Experimental morphine addiction: method of automatic intravenous injections in unrestrained rats. Science 138, 143–144 (1962)

    Google Scholar 

  • Wikler, A., Martin, W. R., Pescor, F. T., Eades, C. G.: Factors regulating oral consumption of an opioid (Etonitazine) by morphine addicted rats. Psychopharmacologia (Berl.) 5, 55–76 (1963)

    Google Scholar 

  • Zajac, M.: Technical solution of the problem of investigation of instrumental conditioned reflex with intragastric reinforcement. Acta physiol. pol. 24, 485–489 (1973)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This investigation was supported by the Polish Academy of Sciences under Agreement No. 09.4.1.1.4.2 for research on “Central regulation of alimentary activity”.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Trojniar, W., Cytawa, J., Frydrychowski, A. et al. Intragastric self-administration of morphine as a measure of addiction. Psychopharmacologia 37, 359–364 (1974). https://doi.org/10.1007/BF00428922

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00428922

Key words

Navigation