Abstract
250 mg/kg of l-alpha-methyl-Dopa (α-m-Dopa) or saline were administered to rats for three weeks after birth. Subsequent tests revealed an increased locomotor activity and greater rate of acquisition but no disturbance in shuttle-box conditioning. The whole brain content of norepinephrine, dopamine and serotonin was not affected.
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Astic, L., Jouvet-Mounier, D.: Mise en évidence du sommeil paradoxal in utero chez le Cobaye. C. R. Acad. Sci. (Paris) 264, 2578–2581 (1969)
Bogdansky, D. F., Pletscher, A., Brodie, B. B., Udenfriend, S.: Identification and assay of serotonin in the brain. J. Pharmacol, exp. Ther. 117, 82–88 (1957)
Carlier, E., Nowaczyk, T., Valatx, J. L., Juvancz, P.: Etude du sommeil du raton nouveau-né isolé de sa mère. Effets de l-alpha-méthyl-Dopa. Psychopharmacologia (Berl.) 37, 205–215 (1974)
Delorme, F.: Monoamines et sommeils. Etude polygraphique neuropharmacologique et histochimique des états de sommeil chez le chat. Thèse de Médecine, Lyon, p. 168 (1966)
von Euler, U. S., Lishajko, F.: Improved technique for the fluorometric estimation of catecholamines. Acta Physiol. Scand. 51, 348–355 (1961)
Fleming, R. M., Clark, W. G., Fenster, E. D., Towne, J. C.: Single extraction method for the simultaneous fluorometric determination of serotonin, dopamine and norepinephrine in the brain. Analyt. Chem. 37, 692–696 (1965)
Jouvet-Mounier, D.: Ontogénèse des états de vigilance chez quelques mammifères. Thèse de Sciences, Lyon, Tixier, p. 231 (1968)
Kitahama, K.: Contribution à l'étude de la relation sommeil-apprentissage. Effets de la privation de sommeil paradoxal par l-alpha-méthyl-Dopa. Thèse Doctorat d'Université, Lyon, p. 98 (1973)
Matsuyama, S., Coindet, J., Mouret, J.: 6-Hydroxydopamine intracisternale et sommeil chez le rat. Brain Res. 57, 85–95 (1973)
Mouret, J., Jouvet, M.: Insomnia following parachlorophenylalanine in the rat. Europ. J. Pharmacol. 5, 17–22 (1968)
Pappas, B. A., Sobrain, S. K.: Neonatal sympathectomy by 6-hydroxydopamine in the rat: no effects on behavior but changes in endogenous brain norepinephrine. Life Sci. 11, 653–659 (1972)
Schaeffer, G. J., Bunchan, D. C., Ray, O. S.: The effects of early p-chlorophenylalanine administration and postweaning housing conditions on serotonin and behavior in rats. Life Sci. 12, 401–411 (1973)
Smith, R. D., Cooper, B. R., Breese, G. R.: Growth and behavioral changes in developing rats treated intracisternally with 6-hydroxydopamine: evidence for involvement of brain dopamine. J. Pharmacol, exp. Ther. 185, 609–619 (1973)
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With IUPHAR fellowship.
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Juvancz, P., Nowaczyk, T. Effects of early post-natal α-methyl-Dopa treatment on behavior in the rat. Psychopharmacologia 42, 95–97 (1975). https://doi.org/10.1007/BF00428832
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DOI: https://doi.org/10.1007/BF00428832