Abstract
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1.
The administration of 15 mg/kg tranylcypromine sulphate (Tc) to rats which have been given lithium chloride (LiCl) in the diet (30 mmol/kg dry food) for 14 days produces hyperactivity within 4 hrs, and this lasts for at least 4 further hours.
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2.
If LiCl is replaced by rubidium chloride (RbCl) at the same dose, the hyperactivity following Tc is increased and it appears within 2 hrs.
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3.
5-Hydroxytryptamine (5HT) accumulation after a monoamine oxidase inhibitor (Tc) is increased 46% and 85% respectively above control values by LiCl and RbCl administration.
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4.
The hyperactivity produced by the above combinations is inhibited by α-methyl-p-tyrosine (αmpt). The inhibition is more effective following LiCl than RbCl treatment.
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5.
After sodium chloride (NaCl) and LiCl treatment, but not after RbCl treatment, the combination of αmpt and Tc produces rat brain concentrations of dopamine (DA) significantly below control values.
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6.
The smaller increase of brain noradrenaline (NA) after Tc and RbCl suggests that a lower percentage of NA is being metabolised by MAO. The greater decrease of NA after giving αmpt to RbCl and LiCl treated rats suggests an increased “turnover” rate of Na.
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7.
The hyperactivity syndrome seen in rats after the administration of LiCl or RbCl and Tc is dependent upon both 5HT and dopamine mechanisms.
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Judd, A., Parker, J. & Jenner, F.A. The role of noradrenaline, dopamine and 5-hydroxytryptamine in the hyperactivity response resulting from the administration of tranylcypromine to rats pretreated with lithium or rubidium. Psychopharmacologia 42, 73–77 (1975). https://doi.org/10.1007/BF00428829
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DOI: https://doi.org/10.1007/BF00428829