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Psychopharmacologia

, Volume 42, Issue 1, pp 27–32 | Cite as

Levels of pyridoxine and susceptibility to electroconvulsive and audiogenic seizures

  • Kurt Schlesinger
  • Bernard Lieff
Animal Studies

Abstract

The effects of pyridoxine deficiency and the administration of supplemental vitamin B6 on audiogenic and electroconvulsive seizures were studied in two inbred strains of mice and their F1 hybrids. Pyridoxine deficient diets increased seizure risk, whereas supplemental vitamin B6 protected these animals against seizures. Penicillamine and thiosemicarbazide, at doses which lowered brain levels of pyridoxine by only 10%, increased seizure risk. Diets deficient in zinc and copper did not alter susceptibility to either audiogenic or electroconvulsive seizures. DBA/2J mice, genetically susceptible to audiogenic seizures, have the same endogenous levels of pyridoxine in the brain as do C57B1/6J mice, which are resistant to audiogenic seizures.

Key words

Pyridoxine Audiogenic Seizures Electroconvulsive Seizures 

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • Kurt Schlesinger
    • 1
  • Bernard Lieff
    • 1
  1. 1.Department of Psychology and Institute for Behavioral GeneticsUniversity of ColoradoBoulder

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