, Volume 47, Issue 1, pp 93–96 | Cite as

Barbital alteration of central nervous system sensitivity to hexobarbital in the rat

  • R. C. Schnell
  • R. E. Stoll
  • T. D. Prosser
Laboratory Studies


Alteration in central nervous system (CNS) sensitivity to the hypnotic effect of the hexobarbital was assessed by analytical, electroencephalographic, and pharmacokinetic techniques in barbital-treated rats. Each of these conceptually diverse experimental methodologies yielded similar conclusions concerning the alteration of CNS sensitivity by barbital treatment.

Key words

CNS Sensitivity Hexobarbital Barbital Rats 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • R. C. Schnell
    • 1
  • R. E. Stoll
    • 1
  • T. D. Prosser
    • 1
  1. 1.Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal SciencesPurdue UniversityWest LafayetteUSA

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