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Psychopharmacology

, Volume 47, Issue 1, pp 81–86 | Cite as

A comparison of the effects of flurazepam 30 mg and triazolam 0.5 mg on the sleep of insomniacs

  • Gerald W. Vogel
  • Katherine Barker
  • Pauline Gibbons
  • Arthur Thurmond
Human Pharmacology

Abstract

The effects of oral, bedtime triazolam 0.5 mg and flurazepam 30 mg, on the laboratory sleep of 12 insomniacs were compared in a double blind, crossover study. A 22 consecutive night schedule was used: Nts. 1–2 placebo; 3–6 first drug; 7–8 placebo; 9–14 no drugs; 15–16 placebo; 17–20 second drug; 21–22 placebo. In 6 Ss first drug was triazolam and second drug was flurazepam. In the other 6 Ss the drug order was reversed. Effects on sleep were assessed objectively by conventional EEG/EOG/EMG sleep recordings and subjectively by questionnaires administered each morning. Side or toxic effects were assessed by physical exams, clinical lab tests, and twice daily questionnaires. During their administration the two drugs were practically indistinguishable in their effects. Both significantly reduced objective and subjective measures of insomnia, such as total wake time and sleep latency. On discontinuation the drugs differentially affected sleep, e.g., on the first post flurazepam night total sleep time was significantly more than baseline whereas on first post triazolam night, total sleep time was significantly less than baseline. There were no remarkable side or toxic effects with either drug.

Key words

Sleep Insomnia Benzodiazepines Flurazepam Triazolam 

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References

  1. Akindele, M. O., Evans, J. I., Oswald, I.: Mono-amine oxidaze inhibitors, sleep and mood. Electroenceph. clin. Neurophysiol. 29, 47–56 (1970)Google Scholar
  2. Dunleavy, D. L. F., Oswald, I.: Phenelzine, mood response, and sleep. Arch. gen. Psychiat. 28, 353–356 (1973)Google Scholar
  3. Greenblatt, D. J., Shader, R. I., Koch-Weser, J.: Flurazepam hydrochloride. Clin. Pharmacol. Ther. 17, 1–14 (1975)Google Scholar
  4. Kales, A., Allen, C., Scharf, M. B., Kales, J.: Hypnotic drugs and their effectiveness. Arch. gen. Psychiat. 23, 226–232 (1970)Google Scholar
  5. Kales, J., Kales, A., Bixler, E. O., Slye, E. S.: Effects of placebo and flurazepam on sleep patterns in insomniac subjects. Clin. Pharmacol. Ther. 12, 691–697 (1971)Google Scholar
  6. Kales, A., Malstrom, E. J., Scharf, M. B., Rubin, R. T.: Psychophysiological and biochemical changes following use and withdrawal of hypnotics. In: Sleep physiology and pathology. A Symposium, A. Kales, ed., pp. 331–343. Philadelphia: J. P. Lippincott 1969Google Scholar
  7. Rechtschaffen, A., Kales, A.: A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. U.S. Dept. HEW Public Health Service, NIH Publication No. 204. Bethesda, Maryland: National Institute of Neurological Diseases and Blindness, Neurological Information Network 1968Google Scholar
  8. Siegel, S.: Nonparametric statistics for the behavioral sciences. New York: McGraw-Hill 1956Google Scholar
  9. Upjohn Company, Kalamazoo, Michigan: Material on file with clinical pharmacology sectionGoogle Scholar
  10. Vogel, G. W.: REM deprivation. III. Dreaming and psychosis. Arch. gen. Psychiat. 18, 312–329 (1968)Google Scholar
  11. Vogel, G. W., Thompson, F. C., Thurmond, A., Rivers, B. A.: The effect of REM deprivation on depression. Psychosomat. 14, 104–107 (1973)Google Scholar
  12. Vogel, G., Thurmond, A., Gibbons, P., Edwards, K., Sloan, K. B., Sexton, K.: The effect of triazolam on the sleep of insomniacs. Psychopharmacologia (Berl.) 41, 65–69 (1975)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Gerald W. Vogel
    • 1
    • 2
  • Katherine Barker
    • 1
    • 2
  • Pauline Gibbons
    • 1
    • 2
  • Arthur Thurmond
    • 1
    • 2
  1. 1.Sleep Laboratory, Georgia Mental Health InstituteEmory UniversityAtlantaU.S.A.
  2. 2.Department of PsychiatryEmory UniversityAtlantaU.S.A.

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