Abstract
Pregnant rats were fed a regimen of ethanol and metrecal from the tenth day of pregnancy until delivery. Control females received metrecal and an isocaloric replacement of ethanol with sucrose. Tyrosine hydroxylase activity was measured in the caudate nuclei of the offspring at 1, 2 and 3 weeks of age. The activity of the enzyme was found to be significantly increased in pups whose mothers were exposed to ethanol.
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Auroux, M., Dehaupas, M.: Influence de la nutrition de la mère sur le développement tardif du système nerveux central de la progeniture. C. R. Soc. Biol. (Paris) 164, 1432 (1970)
Branchey, L., Friedhoff, A. J.: Unpublished data (1972)
Clouet, D.: Narcotic drugs: biochemical pharmacology. D. Clouet, ed. New York: Plenum Press 1971
Coyle, J. T., Axelrod, J.: Tyrosine hydroxylase in rat brain: developmental characteristics. J. Neurochem. 19, 1117–1123 (1972)
Friedhoff, A. J., Miller, J.: Effect of ethanol on biosynthesis of dopamine. In: Proceedings of National Council on Alcoholism. F. A. Seixas, ed. Miami, Florida: Symposia Specialists 1972 (in press, 1973)
Hoffeld, D. R., Webster, R. L.: Effect of injection of tranquilizing drugs during pregnancy of offspring. Nature (Lond.) 13, 1070–1072 (1965)
Hoffeld, D. R., McNew, J., Webster, R. L.: Effect of tranquilizing drugs during pregnancy on activity of offspring. Nature (Lond.) 218, 357–358 (1968)
Huttunen, M. O.: Persistent alteration of turnover of brain nordrenaline in the offspring of rats subjected to stress during pregnancy. Nature (Lond.) 230, 53–55 (1971)
McGeer, E. G., Fibiter, H. C., Wickson, V.: Differential development of caudate enzymes in the neonatal rat. Brain Res. 32, 433–440 (1971)
Nagatsu, T., Levitt, L., Udenfriend, S.: A rapid and simple radioassay for tyrosine hydroxylase activity. Analyt. Biochem. 9, 122–126 (1964a)
Nagatsu, T., Levitt, L., Udenfriend, S.: Tyrosine hydroxylase: The initial step in norepinephrine biosynthesis. J. biol. Chem. 293, 2910–2917 (1964b)
Reichle, F., Goodman, P., Reichle, R. M., Labinsky, L., Rosemond, G.: The effect of acute ethanol administration on brain dopamine, serotonin and norepinephrine. Fed. Proc. 30, 382 (1971)
Shoemaker, W. J., Wurtman, R. J.: Perinatal undernutrion accumulation of catecholamines in rat brain. Science 171, 1017–1019 (1971)
Traylor, T. D., Breese, C. R.: Effect of 6-hydroxydopamine on brain tyrosine hydroxylase and growth of the developing rat. Fed. Proc. 30, 334 (1971)
Truitt, E., Duritz, G.: Biochemical factors in alcoholism, R. Maickel, ed. Oxford-New York: Pergamon Press 1967
Vernadakis, A., Clark, C.: Effects of prenatal administration of psychotropic drugs to rats on butylcholinesterase activity at birth. Brain Res. 21, 4460–463 (1970)
Vincent, N. M.: The effects of prenatal alcoholism upon motivation, emotionality and learning. Amer. Psychologist 13, 401 (1958)
Werboff, J., Dembicki, E.: Toxic effects of tranquilizers administered to gravid rats. J. Neuropsychiat. 4, 87–91 (1962)
Werboff, J., Kesner, R.: Learning deficits of offspring after administration of tranquilizing drugs to the mothers. Nature (Lond.) 197, 106–107 (1963)
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Branchey, L., Friedhoff, A.J. The influence of ethanol administered to pregnant rats on tyrosine hydroxylase activity of their offspring. Psychopharmacologia 32, 151–156 (1973). https://doi.org/10.1007/BF00428685
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DOI: https://doi.org/10.1007/BF00428685