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Psychopharmacology

, Volume 83, Issue 4, pp 357–362 | Cite as

Ingestive behaviour of the pigeon: Stereoselective influence of the opiate agonist levorphanol and its antagonism by naloxone

  • P. Deviche
  • G. Schepers
Original Investigations

Abstract

Four experiments evaluated the effect of levorphanol on ingestive behaviour of different groups of non-deprived pigeons. In experiments 1 and 2, levorphanol and its (+)stereoisomer dextrorphan were administered at three doses (0.25, 1 and 2 mg). As compared with control values, levorphanol dose-dependently reduced food intake. This anorexia persisted for at least 5 h post-injection. A late hyperdipsia was also observed. These changes were stereoselective, suggesting that they followed the binding of levorphanol to opiate receptors. In experiments 3 and 4, the anorexic effect of 1 mg levorphanol, but not its hyperdipsic effect, was partly antagonized by the concomitant administration of either 0.25 mg or 1 mg naloxone. Given alone at the dose of 1 mg, naloxone slightly and transiently reduced food, but not water, intake. These results are discussed in terms of the endorphinergic regulation of ingestive behaviour in birds.

Key words

Drinking Feeding Levorphanol Naloxone Opiates Stereoselectivity Pigeon 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • P. Deviche
    • 1
  • G. Schepers
    • 1
  1. 1.Psychologisches Institut, Experimentelle TierpsychologieRuhr-Universität BochumBochum 1Federal Republic of Germany

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