, Volume 83, Issue 4, pp 304–315 | Cite as

Multiple sites of action for anxiogenic drugs: Behavioural, electrophysiological and biochemical correlations

  • Sharon Pellow
  • Sandra E. File


This review describes animal models of anxiety that are able to identify an anxiogenic drug effect. Evidence is reviewed for the anxiogenic action of several drugs that act at the GABA-benzodiazepine-chloride ionophore complex in the brain. The effects of their combinations with various other drugs thought to act at the same sites are discussed. The classification of these drugs on the basis of their behavioural profiles is compared with their classification based on biochemical and electrophysiological studies.

Key words

Anxiety Social interaction Conflict Drug discrimination Ro 15-1788 CGS 8216 β-carbolines Ro 5-4864 Ro 5-3663 Picrotoxin Pentylenetetrazol Benzodiazepine receptors Picrotoxinin site 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Sharon Pellow
    • 1
  • Sandra E. File
    • 1
  1. 1.MRC Neuropharmacology Research Group, Department of Pharmacology, The School of PharmacyUniversity of LondonLondonUK

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