Virchows Archiv A

, Volume 387, Issue 1, pp 107–116 | Cite as

Serum alpha-fetoprotein-positive gastric carcinoid with liver metastasis

  • Hiroshi Mori
  • Morikazu Onji
  • Aichi Yoshida
  • Ryo Fukunishi
Case Reports


The patient was a 60-year-old Japanese male. He complained of epigastralgia and right chest pain of 4 month's duration, and general malaise, nausea and vomiting of 2 month's duration. Physical examination revealed on the right third rib a tender mass with a diameter of 2 cm and hepatomegaly with a multi-nodular surface and red palms. There were no signs of carcinoid syndrome, such as cutaneous flushing. Laboratory examinations disclosed certain biochemical alterations; alkaline phosphatase 810 IU/l, γ-glutamyl transpeptidase (γ-GTP) 2090 IU/l, carcinoembryonic antigen (CEA) 23.5 ng/ml and α-fetoprotein (AFP) 6,800 ng/ml. Both HBs-Ag and HBs-Ab were negative. The patient died in a uremic state, with rapid increases of jaundice and ascites.

Autopsy revealed gastric carcinoid with extensive metastases to the liver and the bone marrow. Tumor cells showed argyrophilia but not argentaffinity. Immunofluorescence specific for AFP was positive in the hepatocytes, particularly those adjacent to the metastatic tumor cells but not in the tumor cells, either primary or secondary.

79 Cases reported in Japan of serum AFP-positive malignant tumor other than hepatocullular carcinoma and certain other malignancies of germ cell origin are reviewed and discussed.

Key words

α-fetoprotein (AFP) Carcinoembryonic antigen (CEA) Carcinoid (tumor) Gastric cancer Metastatic liver tumor 


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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • Hiroshi Mori
    • 1
  • Morikazu Onji
    • 2
  • Aichi Yoshida
    • 1
  • Ryo Fukunishi
    • 1
  1. 1.Department of PathologyEhime University School of MedicineEhimeJapan
  2. 2.Department of Internal MedicineEhime University School of MedicineEhimeJapan

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