, Volume 85, Issue 2, pp 129–132 | Cite as

Effects of some dibenzo-azepines on suppressed and nonsuppressed behavior of squirrel monkeys

  • Roger D. Spealman
Original Investigations


Six dibenzo-azepine derivatives were compared for their effects on suppressed and nonsuppressed behavior of squirrel monkeys. Monkeys responded by pressing a lever under a two-component fixed-ratio schedule of food presentation in which responding in one component was suppressed by response-produced electric shock. Intermediate doses (0.3–1.0 mg/kg IM) of selected unsubstituted and 8-chlorine-substituted dibenzo-azepines (perlapine, 106-094, and clozapine) increased responding that was suppressed by electric shock, whereas selected 2-chlorine-substituted dibenzo-azepines (loxapine, clothiapine, and 105-056) did not consistently increase suppressed responding at any dose (0.001–0.1 mg/kg IM). All six dibenzo-azepines decreased nonsuppressed responding in a dose-related manner, with the 2-chlorine-substituted derivatives being 16–50 times more potent than their unsubstituted or 8-chlorine-substituted congeners. These structure-activity relationships indicate that the effects of the dibenzo-azepines on both suppressed and nonsuppressed behavior differ qualitatively depending on the location of the chlorine substituent.

Key words

Dibenzo-azepines Suppressed behavior Schedule-controlled behavior Fixed-ratio schedule Squirrel monkeys 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Roger D. Spealman
    • 1
  1. 1.Laboratory of Psychobiology, Department of Psychiatry, Harvard Medical SchoolBoston and New England Regional Primate Research CenterSouthboroughUSA

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