, Volume 66, Issue 3, pp 297–300 | Cite as

The effect of propranolol phentolamine and pimozide on drug-induced anorexia in the mouse

  • S. Dobrzanski
  • N. S. Doggett
Original Investigations


Pimozide was a potent antagonist of (-)amphetamine, diethylpropion, mazindol and phentermine anorexia in the mouse. Phentolamine and propranolol produced no such antagonism, but either potentiated or had no effect on the drug-induced anorexia. Although the mechanism of action of the four anorectic agents appears to involve dopamine receptor agonist activity, an antagonist or partial agonist effect at noradrenergic receptors may also be involved.

Key words

(+)Amphetamine Diethylproprion Mazindol Phentermine Noradrenergic receptors Dopaminergic receptors 


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  1. Abdallah, A. H., Roby, D. M., Boeckler, W. H., Riley, C. C.: Role of DA in the stimulant effect of DITA in mice: Comparisons with d-amphetamine. Eur. J. Pharmacol. 35, 29–34 (1976)Google Scholar
  2. Conte, M., Lehr, D., Goldman, W., Krukowski, M.: The inhibition of food intake by β-adrenergic stimulation. Pharmacologist 10, 180 (1968)Google Scholar
  3. Dobrzanski, S., Doggett, N. S.: Studies in mice on the antagonism of (+)-amphetamine anorexia by α-methyl-p-tyrosine methyl ester HCl. Neuropharmacology 15, 619–623 (1976)Google Scholar
  4. Doggett, N. S., Spencer, P. S. J.: Pharmacological properties of centrally administered agents which interfere with neurotransmitter function: A comparison with the central depressant effects of ouabain. Br. J. Pharmacol. 47, 26–38 (1973)Google Scholar
  5. Frey, H. H., Schulz, R.: On the central mediation of anorexigenic drug effects. Biochem. Pharmacol. 22, 3041–3050 (1973)Google Scholar
  6. Haley, T. J., McCormick, W. G.: Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br. J. Pharmacol. Chemother. 12, 12–15 (1957)Google Scholar
  7. Leibowitz, S. F.: Central adrenergic receptors and the regulation of hunger and thirst. Res. Publ. Assoc. Nerv. Ment. Dis. 50, 327–358 (1972)Google Scholar
  8. Sanghvi, I. S., Singer, G., Friedman, E., Gershon, S.: Anorexigenic effects of d-amphetamine and L-dopa in the rat. Pharmacol. Biochem. Behav. 3, 81–86 (1975)Google Scholar
  9. Shoeman, D. W., Sirtori, C. R., Azarnoff, D. L.: Inhibition of amphetamine tolerance and metabolism by propranolol. J. Pharmacol. Exp. Ther. 191, 68–71 (1974)Google Scholar
  10. Smith, R. L., Dring, L. G.: Patterns of metabolism of β-phenylisopropylamines in man and other species. In: International symposium on amphetamines and related compounds, E. Costa, S. Garratini, eds., pp. 121–139. New York: Raven 1970Google Scholar
  11. Valzelli, L., Consolo, S., Morpurgo, C.: Influence of imipramine like drugs on the metabolism of amphetamine. In: First international symposium on antidepressant drugs. S. Garratini, M. N. G. Dukes, eds., pp. 61–69. Amsterdam: Excerpta Medica 1967Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • S. Dobrzanski
    • 1
  • N. S. Doggett
    • 1
  1. 1.Department of Pharmacology, Welsh School of PharmacyUniversity of Wales Institute of Science and TechnologyCardiffUK

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