Psychopharmacology

, Volume 66, Issue 3, pp 297–300 | Cite as

The effect of propranolol phentolamine and pimozide on drug-induced anorexia in the mouse

  • S. Dobrzanski
  • N. S. Doggett
Original Investigations

Abstract

Pimozide was a potent antagonist of (-)amphetamine, diethylpropion, mazindol and phentermine anorexia in the mouse. Phentolamine and propranolol produced no such antagonism, but either potentiated or had no effect on the drug-induced anorexia. Although the mechanism of action of the four anorectic agents appears to involve dopamine receptor agonist activity, an antagonist or partial agonist effect at noradrenergic receptors may also be involved.

Key words

(+)Amphetamine Diethylproprion Mazindol Phentermine Noradrenergic receptors Dopaminergic receptors 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • S. Dobrzanski
    • 1
  • N. S. Doggett
    • 1
  1. 1.Department of Pharmacology, Welsh School of PharmacyUniversity of Wales Institute of Science and TechnologyCardiffUK

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