Abstract
d-Methylamphetamine (1–4 mg/kg) induced wakefulness for 3–5 h followed by paradoxical sleep (PS) rebound in C57BR, C57BL/6, and BALB/c mice. Slow-wave sleep (SWS) and PS suppression time were proportional to the given dose and different among strains. It was also dependent on the time of injection. Later PS rebound was significant in C57 strains, and in certain cases greater than PS loss, whereas rebound was small in BALB/c mice and PS loss was not completely compensated.
Similar content being viewed by others
References
Anisman, H.: Effects of scopolamine and d-amphetamine on locomotor activity before and after shock: A diallellic analysis in mice. Psychopharmacology 48, 165–173 (1976)
Ciaranello, R. D., Barchas, R., Kessler, S., Barchas, J. D.: Catecholamines: Strain differences in biosynthetic enzyme activity in mice. Life Sci. 11, 565–572 (1972)
Dusan-Peyrethon, D., Peyrethon, J., Jouvet, M.: Suppression élective du sommeil paradoxal chez le chat par 1′α-méthyl-dopa. C. R. Soc. Biol. 162 116–118 (1968)
Eleftheriou, B. E.: Regional brain norepinephrine turnover rates in four inbred strains of mice. Neuroendocrinology 7, 329–336 (1971)
Glowinski, J., Axelrod, J.: Effects of drugs on the uptake release and metabolism of H3-norepinephrine in the rat brain. J. Pharmacol. Exp. Ther. 149, 43–49 (1965)
Hanson, L. C. F.: Evidence that the central action of (+)amphetamine is mediated via catecholamines. Psychopharmacologia 10, 289–298 (1967)
Hartman, E., Cravens, J.: Sleep: Effects of d- and l-amphetamine in man and in rat. Psychopharmacology 50, 171–175 (1976)
Hiebel, G., Bonvallet, M., Hube, P., Dell, P.: Analyse neurophysiologique de l'action centrale de la d-amphétamine (maxiton). Sem. Hop. 30, 1880–1885 (1954)
Javoy, F., Thierry, A. M., Kety, S. S., Glowinski, J.: The effects of amphetamine on the turnover of brain norepinephrine in normal and stressed rats. Commun. Behav. Biol. 1A, 43–48 (1968)
Jori, A., Rutczynski, M.: A genetic analysis of the hyperthermic response to d-amphetamine in two inbred strains of mice. Psychopharmacology 59, 199–203 (1978)
Jouvet M: The role of monoamines and acetylcholine containing neurons in the regulation of the sleep-waking cycle. Ergeb. Physiol. 64, 166–307 (1972)
Kempf, E., Graeilshmer, J., Mack, G., Mandel, P.: Correlation of behavioral differences in three strains of mice with differences in brain amines. Nature 247, 483–485 (1974)
Kitahama, K.: Etude neuro-psycho-pharmaco-génétique sur la relation sommeil-apprentissage. Thèse d'État ès Sciences, pp. 203 (1979)
Kitahama, K., Valatx, J. L.: Strain differences in amphetamine sensitivity in mice. I. A diallellic analysis of open field activity. Psychopharmacology 66, 189–194 (1979)
Kitahama, K., Valatx, J. L.: Action de l'alpha-méthyl-DOPA sur les rythmes veille sommeil de souris C57BR et C57BL/6. Psychopharmacologia 45, 189–196 (1975a)
Kitahama, K., Valatx, J. L.: Effets du chloramphenicol et du thiamphenicol sur le sommeil de la souris. C. R. Soc. Biol. 169, 1522–1525 (1975b)
Kitahama, K., Valatx, J. L.: Genetic study of instrumental and pharmacological paradoxical sleep deprivation in mice. Neuropharmacology (in press 1979)
Leppavuori, A., Putkonen, P. T. S.: Evidence for central alpha-adrenoreceptor stimulation as the basis of paradoxical sleep suppression by alpha-methyl-dopa. Neurosci. Letters 9, 37–43 (1978)
Lewander, T.: Effect of chronic treatment with central stimulant on brain monoamines and some behavioral and physiological functions in rats, guinea pigs and rabbits. In: Neuropharmacology of monoamines and their regulatory enzymes, E. Usdin, ed., pp. 221–239. New York: Raven 1974
Maj, J.: Dopaminergic drugs effects upon serotonin neurons. In: Current developments in psychopharmacology, V. Essman, W. Valzelli, eds., pp. 55–83. New York: Spectrum 1976
Moisset, B.: Genetic analysis of the behavioral response to d-amphetamine in mice. Psychopharmacology 53, 263–267 (1977)
Natali, J. P., McRae-Degueurce, A., Keane, P., Debilly, G., Pujol, J. F.: Genetic studies of daily variations of first-step enzymes of monoamines metabolism in the brain of inbred strains of mice and hybrids. Daily variations of tyrosine hydroxylase activity in the locus coeruleus. Brain Res. (in press 1979)
Oliverio, A., Eleftheriou, B. E., Bailey, D. W.: Exploratory activity: Genetic analysis of its modification by scopolamine and amphetamine. Physiol. Behav. 10, 893–899 (1973)
Oswald, I.: Human brain protein, drugs and dreams. Nature 223, 893–897 (1969)
Petitjean, F., Sastre, J. P., Bertrand, N., Cointy, C., Jouvet, M.: Suppression du sommeil paradoxal par le chloramphenicol chez le chat. Absence d'effet du thiamphenicol. C. R. Soc. Biol. 169, 1236–1239 (1975)
Rechtschaffen, A., Maron, L.: Effect of amphetamine on the sleep cycle. Electroencephalogr. Clin. Neurophysiol. 16, 438–445 (1964)
Ross, R. A., Judd, A. B., Pickel, V. M., Joh, T. H., Reis, D. J.: Strain-dependent variations in number of midbrain dopaminergic neurones. Nature 264, 654–656 (1976)
Salomon, R.: The effect of amphetamine on culture myotubes: Selective inhibition of protein synthesis. Life Sci. 23, 1941–1950 (1978)
Segal, D. S., Geyer M. A., Weiner, B. E.: Strain differences during intraventricular infusion of norepinephrine. Possible role of receptor sensitivity. Science 189, 301–303 (1975)
Tunnicliff, G., Wimer, C. C., Wimer, R. E.: Relationships between neurotransmitter metabolism and behavior in seven inbred strains of mice. Brain Res 61, 428–434 (1973)
Valatx, J. L., Bugat, R.: Facteurs génétiques dans le déterminisme du cycle veille-sommeil chez la souris. Brain Res. 69, 315–330 (1974)
Vimont-Vicary, P.: La suppression des différents états de sommeil. Etude comportementale, EEG et neuropharmacologique chez le chat. Thèse Médecine, Lyon 1965
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kitahama, K., Valatx, JL. Strain differences in amphetamine sensitivity in mice. Psychopharmacology 66, 291–295 (1979). https://doi.org/10.1007/BF00428322
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00428322