, Volume 66, Issue 3, pp 251–255 | Cite as

Effects of a histamine synthesis inhibitor and antihistamines on the sexual behavior of female rats

  • A. O. Donoso
  • S. T. Broitman
Original Investigations


Intraventricular administration of α-hydrazinohistidine, a histamine synthesis inhibitor, at different doses and times before testing produced a significant decrease of lordotic responses and sexual receptivity in ovariectomized estrogen plus progesterone-primed female rats. The H1-antihistamines pyrilamine and chlorfeniramine and the H2-antihistamine metiamide, injected in the lateral ventricle, significantly decreased the lordosis quotient but did not modify receptivity; antihistamine-injected rats showed no soliciting behavior. Exploratory activity was decreased by both α-hydrazinohistidine and metiamide but not by the H1-antihistamines. It is concluded that treatments which either deplete histamine or block their receptors can alter female copulatory responsiveness. The mechanism of this antihistamine effect appears to be unrelated to that of other side effects, such as motor impairment, sedation, or local anesthesia.

Key words

α-Hydrazinohistidine Pyrilamine Metiamide Chlorfeniramine Female sexual behavior Histamine 


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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • A. O. Donoso
    • 1
  • S. T. Broitman
    • 1
  1. 1.Instituto de Investigaciones Cerebrales, Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendozaArgentina

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