Abstract
The relationship between wet-dog shaking (WDS) and afterdischarge (AD) elicited by dorsal hippocampal stimulation was investigated. The number of the WDS during a 150-s observation period was 9.6±2.0 (mean ± SEM) and no WDS was seen during the non-seizure period. The effects of morphine and neuroleptics on WDS and AD were also investigated. Morphine significantly inhibited the number of WDS elicited by hippocampal stimulation. Naloxone significantly antagonized the inhibitory effect of morphine. Haloperidol and chlorpromazine significantly and dose-dependently inhibited the number of WDS at very small doses. The inhibitory effect of chlorpromazine on WDS was not antagonized by pretreatment with nalozone. The present results suggest that central dopaminergic mechanisms may be important in WDS elicited by hippocampal stimulation. The effect of morphine on WDS is probably mediated via an opioid receptor having a modulating effect on central dopaminergic mechanisms.
Similar content being viewed by others
References
Aihara H, Araki H, Ohzeki M (1982) Hippocampal kindling and effects of antiepileptic drugs. Jpn J Pharmacol 32:37–45
Bedard P, Pycock CJ (1977) Wet-dog shake behavior in the rat: possible quantative model of central 5-hydroxytryptamine activity. Neuropharmacology 16:663–670
Bloom F, Segal D, Ling N, Guillemin R (1976) Endorphines: Profound behavioral effects in rats suggest new etiological factors in mental illness. Science 194:630–632
Clay GB, Brougham LR (1975) Haloperidol binding to an opiate receptor site. Biochem Pharmacol 24:1363–1367
Creese I, Feinberg PA, Snyder SH (1976) Butyrophenone influences on the opiate receptor. Eur J Pharmacol 36:231–235
De Groot (1959) The forebrain in stereotaxic coordinates. Verch K Acad Wet 52:1–40
Drust EG, Crawford IL (1982) Thyrotropine-releasing hormone (TRH) unlike d-ala2-met-enkephalinamide, evokes shaking behavior without causing electrographic seizures in the rat hippocampus. Fed Proc 41:1508
Fozard JR, Palfreman MG (1979) Metoclomide antagonism of 5-hydroxytryptophan-induced ‘wet-dog’ shake behavior in the rat. Naunyn-Schmiedeberg's Arch Pharmacol 307:135–142
Frunk H, Yitzhaky J (1981) Effects of amygdaloid kindling on the pain threshold of the rat. Exp Neurol 71:487–496
Holaday JW, Loh HH, Li CH (1978) Unique behavioral effects of β-endorphin and their relationship to thermoregulation and hypothalamic function. Life Sci 22:1525–1536
Iwatsubo K, Clouet DH (1977) Effects of morphine and haloperidol on the electrical activity of rat nigrostriatal neurons. J Pharmacol Exp Ther 202:429–436
Kuschinsky K (1976) Actions of narcotics on brain dopamine metanbolism and their relevance for ‘Psychomotor’ effects. Arzneimittel Forsch 26:563–567
Lal H (1975) Narcotic dependence, narcotic action and dopamine receptors. Life Sci 17:483–495
Lanthorn T, Isaacson RL (1978) Studies of kainate-induced wet-dog shake in the rat. Life Sci 22:171–178
Leysen J, Gommerren W, Laduron P (1976) Discrimination of narcotic drugs on 3H-fentanyl receptor binding. Arch Int Pharmacol Ther 220:335–338
Lord JAH, Waterfield AA, Hughes J, Kosterlitz HW (1977) Endogenous opioid peptides: multiple agonists and receptors. Nature 267:495–499
Martin WR, Wikler A, Eades CC, Pescor FT (1963) Tolerance to and physical dependence on morphine in rats. Psychopharmacologia 4:247–260
Persson S-A (1979) Effect of morphine on the accumulation of DOPA after decarboxylase inhibition in the rat. Eur J Pharmacol 55:121–128
Racine R, Rose PR, Burnham WM (1977) Afterdischarge theshold and kindling rates in dorsal and ventral hippocampus and dentate gyrus. Can J Neurol Sci 4:273–278
Turski L, Cruczwar SJ, Turski W, Kleinrok Z (1981) Studies of carbachol-induced wet-dog shake behavior in rats. Psychopharmacology 73:81–83
Wei E (1973) Assessment of precipitated abstinence in morphine dependent rats. Psychopharmacologia 28:35–44
Wei E, Loh HH, Way EL (1973) Quantitative aspects of precipicated abstinence in morphine-dependent rats. J Pharmacol Exp Ther 184:398–408
Wei E, Sigel S, Loh E, Way EL (1975) Thyrotropin-releasing hormone and shaking behavior in rat. Nature 253:739–740
Yamada K, Furukawa T (1981) The yawning elicited by α-melanocyte-stimulating hormone involves serotonergic-dopaminergic-cholinergic neuron link in rats. Naunyn-Schmiedeberg's Arch Pharmacol 316:155–160
Yamada K, Matsuki J, Furukawa T (1983) Wet-dog body shaking induced by electrical stimulation of hippocampus in the intact and reserpinized rat. Res Commun Chem Pathol Pharmacol 39:29–37
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Araki, H., Aihara, H. Effects of morphine and neuroleptics on wet-dog shaking behavior elicited by hippocampal stimulation in rats. Psychopharmacology 85, 301–305 (1985). https://doi.org/10.1007/BF00428191
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00428191