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Psychopharmacology

, Volume 79, Issue 2–3, pp 246–250 | Cite as

Involvement of catecholamines in acute tolerance to ethanol in mice

  • Frances Edwards
  • V. V. Schabinsky
  • D. M. Jackson
  • G. A. Starmer
  • O. Jenkins
Original Investigations

Abstract

The percentage of mice able to remain on a rolling drum for 45 s was recorded at 1.25 min and 30 min after administration of ethanol (2.4 g/kg). Though there was no significant difference in brain ethanol levels at the two test times, performance was markedly different with significantly fewer mice able to remain on the drum at 1.25 min than at 30 min. This phenomenon, known as acute tolerance, was antagonised by pretreating mice with haloperidol (0.4 mg/kg), FLA-63 (25 mg/kg), diethyldithiocarbamate (400 mg/kg), phenoxybenzamine (40 mg/kg), phentolamine (20 mg/kg), yohimbine (3 mg/kg) and clozapine (1 mg/kg), but not by spiperone (0.16 mg/kg), α-methyl-p-tyrosine (300 mg/kg) or phenobarbitone (10 mg/kg). The relative potencies of the effective blocking agents suggest that α2-receptors may play an important role in mediating acute ethanol tolerance.

Key words

Ethanol Acute tolerance α-Adrenergic receptors Noradrenaline 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Frances Edwards
    • 1
  • V. V. Schabinsky
    • 1
  • D. M. Jackson
    • 1
  • G. A. Starmer
    • 1
  • O. Jenkins
    • 1
  1. 1.Department of PharmacologyUniversity of SydneyAustralia

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